The role of lysophosphatidic acid in acute lung injury

• Project/Area Number: 22790745
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: Tohoku University
• Principal Investigator: YAMADA Mitsuhiro 東北大学, 大学院・医学研究科, 助教 (00396483)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 急性肺損傷 / 活性化脂質 / 炎症 / 組織修復 / 細菌性肺炎 / 急性肺傷害

Research Abstract

To elucidate the contribution of ATX and LPA to acid-induced lung injury, we examined the changes in the enzymatic activity of ATX in blood and BALF. We also examined the effect of anti-ATX blocking antibodies on the progression of acid-induced lung injury. We observed that acid instillation increased the enzymatic activity of ATX in BALF. Decreasing ATX activity attenuated the increased pulmonary permeability induced by acid-instillation. These data suggest that ATX and its product LPA are involved in pulmonary edema in acid-induced acute lung injury.

Research Products

• [Journal Article] The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury (2011)
  • Author(s): 山田充啓、久保裕司、小林誠一、石沢興太、何梅、鈴木隆哉、藤野直也、國島広之、八田益光、西巻雄司、青柳哲史、徳田浩一、北川美穂、矢野寿一、玉村啓和、藤井信孝、賀来満夫
  • Journal Title: Cellular & molecular immunology Volume: 8巻 Pages: 305-314
  • Peer Reviewed
• [Journal Article] The Increase in Surface CXCR4 Expression on Lung Extravascular Neutrophils and its Effects on Neutrophils During Endotoxin-Induced Lung Injury (2011)
  • Author(s): Yamada M, Kitagawa M, Yano H, Tamamura H, Fujii N, Kaku M, et al.
  • Journal Title: Cell Mol Immunol Volume: 8 Issue: 4 Pages: 305-314
  • DOI: 10.1038/cmi.2011.8
  • Peer Reviewed
• [Presentation] 急性肺損傷における肺好中球上CXCR4発現上昇の機序とその役割 (2011)
  • Author(s): 山田充啓
  • Organizer: 日本呼吸器学会
  • Place of Presentation: 東京
  • Year and Date: 2011-04-22
• [Presentation] 急性肺損傷における肺好中球上CXCR4発現上昇の機序とその役割 (2011)
  • Author(s): 山田充啓
  • Organizer: 日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-04-22