The role of lysophosphatidic acid in acute lung injury
| Project/Area Number |
22790745
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 急性肺損傷 / 活性化脂質 / 炎症 / 組織修復 / 細菌性肺炎 / 急性肺傷害 |
|---|
| Research Abstract |
To elucidate the contribution of ATX and LPA to acid-induced lung injury, we examined the changes in the enzymatic activity of ATX in blood and BALF. We also examined the effect of anti-ATX blocking antibodies on the progression of acid-induced lung injury. We observed that acid instillation increased the enzymatic activity of ATX in BALF. Decreasing ATX activity attenuated the increased pulmonary permeability induced by acid-instillation. These data suggest that ATX and its product LPA are involved in pulmonary edema in acid-induced acute lung injury.
|
Report
(3 results)
Research Products
(4 results)
