Roles of IL-25 in the development of pulmonary arterial inflammation and remodeling

• Project/Area Number: 22790748
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: Chiba University
• Principal Investigator: IKEDA Kei 千葉大学, 医学部・附属病院, 助教 (10456014)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: IL-25 / 肺血管リモデリング / 肺高血圧

Research Abstract

We generated lung specific IL-25 transgenic (C57BL/6 CC10 IL-25) mice and C57BL/6 CC10 IL-25 NKT cell-deficient mice, and performed histopathological analysis, immune-histochemistry, and gene expression analysis. The results suggest that IL-25-NKT cell pathway is involved in the development of pulmonary arterial muscularization.

Research Products

• [Journal Article] A functional polymorphism in B and T lymphocyte attenuator is associated with susceptibility to rheumatoid arthritis (2012)
  • Author(s): Oki M, Watanabe N, Ikeda K, et al.
  • Journal Title: Clin Dev Immunol Volume: (In press)
  • Peer Reviewed
• [Journal Article] Bucillamine-induced yellow nail in Japanese patients with rheumatoid arthritis : two case reports and a review of 36 reported cases (2012)
  • Author(s): Nakagomi D, Ikeda K, Kawashima H, et al.
  • Journal Title: Rheumatol Int Volume: (In press)
  • Peer Reviewed
• [Journal Article] Int Immunol. Lack of B and T lymphocyte attenuator exacerbates autoimmune disorders and induces Fas-independent liver injury in MRL-lpr/lpr mice (2011)
  • Author(s): Oya Y, Watanabe N, Ikeda K, et al
  • Journal Title: Int Immunol Volume: 23 Pages: 335-344
• [Journal Article] A patient with neuromyelitis optica with positive anti-Ro (SS-A) antibody presenting with intractable hiccup and nausea (2011)
  • Author(s): Koga S, Ikeda K, Nakagomi D, et al
  • Journal Title: Mod Rheumatol Volume: 21 Pages: 561-562
  • NAID: 10030205936
• [Journal Article] Lack of B and T lymphocyte attenuator exacerbates autoimmune disorders and induces Fas-independent liver injury in MRL-lpr/lpr mice (2011)
  • Author(s): Oya Y, Watanabe N, Owada T, Oki M, Ikeda K, Suto A, Kagami S-I, Hirose K, Kishimoto T, Nakajima H
  • Journal Title: Int. Immunol Volume: 23 Issue: 5 Pages: 335-44
  • DOI: 10.1093/intimm/dxr017
  • Peer Reviewed
• [Journal Article] Comparison of low-field dedicated extremity magnetic resonance imaging with articular ultrasonography in patients with rheumatoid arthritis (2011)
  • Author(s): Horikoshi M, Suzuki T, Ikeda K, et al.
  • Journal Title: Mod Rheumatol Volume: 20 Issue: 6 Pages: 556-560
  • DOI: 10.1007/s10165-010-0318-2
  • NAID: 10027647341
  • Peer Reviewed
• [Journal Article] Comparison of low-field dedicated extremity magnetic resonance imaging with articular ultrasonography in patients with rheumatoid arthritis (2010)
  • Author(s): Horikoshi M, Suzuki T, Ikeda K, et al
  • Journal Title: Mod Rheumatol Volume: 20 Pages: 556-560
  • NAID: 10027647341
• [Journal Article] B and T lymphocyte attenuator suppresses IL-21 production from follicular Th cells and subsequent humoral immune responses (2010)
  • Author(s): Kashiwakuma D, Suto A, Ikeda K, et al
  • Journal Title: J Immunol Volume: 185 Pages: 2730-2736
• [Journal Article] Role of Th2 cells in IgG4-related lacrimal gland enlargement (2010)
  • Author(s): Kanari H, Kagami S, Ikeda K, et al
  • Journal Title: Int Arch Allergy Immunol Volume: 152 s1 Pages: 47-53
• [Journal Article] c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-beta inhibits c-Maf-induced IL-21 production in CD4+ T cells (2010)
  • Author(s): Hiramatsu Y, Suto A, Ikeda K, et al
  • Journal Title: J Leukoc Biol Volume: 87 Pages: 703-712
• [Journal Article] B and T lymphocyte attenuator suppresses IL-21 production from follicular Th cells and subsequent humonl immune responses (2010)
  • Author(s): Kashiwakuma D, Suto A, Ikeda K, Nakajima H, et al.
  • Journal Title: J Immunol. Volume: 185 Pages: 2730-2736
  • Peer Reviewed
• [Journal Article] Role of Th2 cells in IgG4-related lacrimal gland enlargement (2010)
  • Author(s): Kanari H, Kagami S, Ikeda k, Nakajima H, et al.
  • Journal Title: Int Arch Allergy Immunol. Volume: 152 Pages: 47-53
  • Peer Reviewed
• [Journal Article] c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-β inhibits c-Maf-induced IL-21 production in CD-T cells (2010)
  • Author(s): Hiramatsu Y, Suto A, Ikeda K, Nakajima H, et al.
  • Journal Title: J Leukoc Biol. Volume: 87 Pages: 703-712
  • Peer Reviewed
• [Journal Article] Protective roles of B and T lymphocyte attenuator in NKT cell-mediated experimental hepatitis (2010)
  • Author(s): Iwata A, Watanabe N, Ikeda K, Hirose K, Nakajima H, et al.
  • Journal Title: J Immunol. Volume: 184 Pages: 127-133
  • Peer Reviewed
• [Journal Article] Bucillamine-induced yellow nail in Japanese patients with rheumatoid arthritis : two case reports and a review of 36 reported cases
  • Author(s): Nakagomi D, Ikeda K, et al
  • Journal Title: Rheumatol Int in press
• [Journal Article] A functional polymorphism in B and T lymphocyte attenuator is associated with susceptibility to rheumatoid arthritis
  • Author(s): Oki M, Watanabe N, Ikeda K, et al
  • Journal Title: Clin Dev Immunol, in press
• [Presentation] New approach through a beneficial tool-The application of ultrasonographic evaluation of synovium in the management of rheumatoid arthritis (2011)
  • Author(s): K. Ikeda
  • Organizer: The 5^<th> Asian Congress on Autoimmunity
  • Place of Presentation: Satellite Symposium. Singapore
  • Year and Date: 2011-11-18
• [Presentation] IgG4関連涙腺腫脹症例におけるPGD2-CRTH2経路の役割の解析 (2011)
  • Author(s): 加々美新一郎, 細川淳一, 池田啓, 他
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Year and Date: 2011-11-10
• [Presentation] The impact of ultrasonography on the classification of rheumatoid arthritis with 2010 ACR/EULAR criteria : ultrasound-combined classification with two different definitions of gray-scale synovitis for joint involvement (2011)
  • Author(s): Nakagomi, K. Ikeda, A. Okubo, et al
  • Organizer: ACR (American College of Rheumatology) Annual Scientific Meeting
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-11-06
• [Presentation] リウマチ性疾患の画像滑膜ドプラ血流測定に対するPRF(Pulse Repetition Frequency)の与える影響の検討 (2011)
  • Author(s): 池田啓, 瀬戸洋平, 大野滋, 他
  • Organizer: 第55回日本リウマチ学会総会・学術集会
  • Year and Date: 2011-07-20
• [Presentation] 生物学的製剤増量、変更関節リウマチ患者はどう評価しているか? (2011)
  • Author(s): 松村竜太郎, 池田啓, 海辺剛志, 他
  • Organizer: 第55回日本リウマチ学会総会・学術集会
  • Year and Date: 2011-07-19
• [Presentation] トシリズマブ関節リウマチ患者の骨代謝に対するトシリズマブの効果 (2011)
  • Author(s): 松浦功, 山形美絵子, 池田啓, 他
  • Organizer: 第55回日本リウマチ学会総会・学術集会
  • Year and Date: 2011-07-19
• [Presentation] 全身性エリテマトーデスの治療中に腸管嚢腫様気腫症および気腫性膀胱炎を合併した一例 (2011)
  • Author(s): 大久保綾子, 岩本太郎, 池田啓, 他
  • Organizer: 第55回日本リウマチ学会総会・学術集会
  • Year and Date: 2011-07-19
• [Presentation] トシリズマブDNAアレイ解析によるトシリズマブの関節リウマチに対する薬効予測 (2011)
  • Author(s): 古田俊介, 山形美絵子, 池田啓, 他
  • Organizer: 第55回日本リウマチ学会総会・学術集会
  • Year and Date: 2011-07-18
• [Presentation] リウマチ性疾患の画像滑膜ドプラ血流測定に対する検者、機器、ならびにプローブの劣化の与える影響の検討 (2011)
  • Author(s): 池田啓, 瀬戸洋平, 大野滋, 他
  • Organizer: 第55回日本リウマチ学会総会・学術集会
  • Year and Date: 2011-07-18
• [Presentation] The impact of ultrasonography on the classification of RA with 2010 ACR/EULAR criteria (2011)
  • Author(s): D. Nakagomi, K. Ikeda, A. Okubo, et al
  • Organizer: EULAR(European League Against Rheumatism)
  • Place of Presentation: Congress, London, UK
  • Year and Date: 2011-05-27
• [Presentation] 気管支喘息患者のQOL調査 (2011)
  • Author(s): 横田雅也, 須藤明, 池田啓, 他
  • Organizer: 第60回日本アレルギー学会春季臨床大会
  • Year and Date: 2011-05-15
• [Presentation] Nutcracker esophagus(NE)を合併した好酸球性食道炎の一例 (2011)
  • Author(s): 大久保綾子, 中込大樹, 池田啓, 他
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Year and Date: 2011-05-15
• [Presentation] 膠原病ならびにリウマチ性疾患患者のQuality of Life調査 (2011)
  • Author(s): 池田啓, 川島広稔, 高橋健太郎, 他
  • Organizer: 第55回日本リウマチ学会総会・学術集会
  • Year and Date: 2011-05-15
• [Presentation] 気管支喘息患者のQOL調査 (2011)
  • Author(s): 横田雅也、須藤明、池田啓, 他
  • Organizer: 第60回日本アレルギー学会春季臨床大会
  • Place of Presentation: 千葉
  • Year and Date: 2011-05-15
• [Presentation] 肺動脈リモデリングにおけるIL-25の働き (2010)
  • Author(s): 丹羽佑輔, 川島沙紀, 池田啓, 他
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Year and Date: 2010-11-27
• [Presentation] 肺動脈リモデリングにおけるIL-25の働き (2010)
  • Author(s): 丹羽佑輔、池田啓, 他
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-27
• [Presentation] 両側視神経炎を合併したChurg-Strauss症候群の一例 (2010)
  • Author(s): 中込大樹, 古賀俊輔, 池田啓, 他
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Year and Date: 2010-11-26
• [Presentation] 両側視神経炎を合併したChurg-Strauss症候群の1例 (2010)
  • Author(s): 中込大樹, 古賀俊輔, 池田啓, 他
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Year and Date: 2010-11-26
• [Presentation] 高用量ステロイド投与中の膠原病患者へのST合剤投与による副作用発現率と危険因子に関する研究 (2010)
  • Author(s): 林彰子, 増田和司, 池田啓, 他
  • Organizer: 第20回日本医療薬学会年会
  • Year and Date: 2010-11-13
• [Presentation] The application and benefit of ultrasonography in rheumatic conditions (2010)
  • Author(s): K. Ikeda
  • Organizer: TLAR (Turkish League Against Rheumatism) Symposium in Antalya : The Benefit of Ultrasonography and Nuclear Medicine in Rheumatic Conditions
  • Place of Presentation: Antalya, Turkey
  • Year and Date: 2010-10-23
• [Presentation] How to evaluate synovial inflammation in each joint with ultrasound in rheumatic conditions (2010)
  • Author(s): K. Ikeda
  • Organizer: TLAR (Turkish League Against Rheumatism) Symposium in Antalya : The Benefit of Ultrasonography and Nuclear Medicine in Rheumatic Conditions
  • Place of Presentation: Antalya, Turkey
  • Year and Date: 2010-10-23
• [Presentation] Comparison of ultrasonographic findings with established measures in the evaluation of drug response in rheumatoid arthritis (2010)
  • Author(s): K. Ikeda, D. Nakagomi, H. Kawashima, et al
  • Organizer: EULAR (European League Against Rheumatism)
  • Place of Presentation: Congress 2010, Roma, Italy
  • Year and Date: 2010-06-18
• [Remarks]
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• [Remarks]
  • URL: http://www.m.chiba-u.jp/class/gene/kenkyugyouseki.html
• [Remarks]
  • URL: http://www.m.chiba-u.jp/class/gene/kenkyugyouseki.html