Investigation of aberrant microRNA expression for smoking. induced lung carcinogenesis

• Project/Area Number: 22790749
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: The University of Tokyo
• Principal Investigator: HAMANO Emi 東京大学, 保健・健康推進本部, 助教 (80466763)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 肺癌 / 喫煙 / マイクロRNA

Research Abstract

The pathogenesis of smoking-induced lung carcinogenesis was explored in terms of alteration of microRNA expression by epigenetic regulation. Genome structure based screening was used to identify epigenetically silenced tumor suppressive miRNAs. The DNA methylation of mir-34b can be used as a biomarker for an invasive phenotype of lung cancer.

Research Products

• [Journal Article] Genome structure-based screening identifiedepigenetically silenced microRNA associated with invasiveness in non-small-cell lung cancer. (2012)
  • Author(s): Watanabe K, Goto A, Takai D.
  • Journal Title: Int J Cancer. Volume: 130 Issue: 11 Pages: 2580-2590
  • DOI: 10.1002/ijc.26254
  • Peer Reviewed
• [Journal Article] CpG island methylation of microRNAs is associated with tumor size and recurrence of non-small-cell lung cancer (2011)
  • Author(s): Kitano K, Watanabe K, Emoto N, Kage H, Hamano E, Nagase T, Sano A, Murakawa T, Nakajima J, Goto A, Fukayama M, Yatomi Y, Ohishi N, Takai D.
  • Journal Title: Cancer Sci Volume: 102 Issue: 12 Pages: 2126-2131
  • DOI: 10.1111/j.1349-7006.2011.02101.x
  • NAID: 10030245653
  • Peer Reviewed
• [Presentation] Genome structure-based screening identified epigenetically silenced microRNA associated with invasiveness in non-small cell lung cancer (2012)
  • Author(s): Watanabe K, Hamano E, et al.
  • Organizer: AACR-IASLC Joint Conference on THE MOLECULAR ORIGINS OF LUNG CANCER
  • Place of Presentation: San Diego Marriot Hotel & Marina(アメリカ)
  • Year and Date: 2012-10-10
• [Presentation] Genome sturucture-based screeening identified epigenetically silenced microRNA associated with invasiveness in non-small cell lung cancer (2012)
  • Author(s): Watanabe K, Hamano E, et al.
  • Organizer: AACR-IASLC Joint Conference on THE MOLECULAR ORIGINS OF LUNG CANCER
  • Place of Presentation: San Diego Marriot Hotel & Marina(アメリカ)
  • Year and Date: 2012-01-10
• [Presentation] CpG island methylation of microRNAs is associated with tumor size and the recurrence of non-small cell lung cancer (2012)
  • Author(s): Kitano K, Hamano E, et al.
  • Organizer: AACR-IASLC Joint Conference on THE MOLECULAR ORIGINS OF LUNG CANCER
  • Place of Presentation: San Diego Marriot Hotel & Marina(アメリカ)
  • Year and Date: 2012-01-09