The role of Leukotrienes in the pathogenesis of pulmonary fibrosis
| Project/Area Number |
22790756
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Shimane University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | ロイコトリエン / 肺線維症 / シリカ |
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| Research Abstract |
We have shown that CysLTs(Cysteinyl leukotrienes) are play important role in the pathogenesis of pulmonary fibrosis in mice model. Especially, CysLTs contribute to the directly to the progression of pulmonary fibrosis, especially in the chronic phase. Furthermore, it is expected that CysLT_1 receptor antagonist may become new therapeutic agent for human pulmonary fibrosis.
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Report
(3 results)
Research Products
(10 results)
