Effects of zincchelator in asthma and interstitialpneumonia model mouse

• Project/Area Number: 22790758
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: Hiroshima University
• Principal Investigator: IWAMOTO Hiroshi 広島大学, 病院, 病院助教 (60457398)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
• Keywords: 気管支喘息 / 亜鉛 / 間質性肺炎

Research Abstract

Free zinc acts as an intracellular messenger in immune cells and thus zinc might be involved in the pathogenesis of respiratory diseases caused by abnormality of immune cells. We tested the effect of zinc chelate agent on asthma and interstitial pneumonia model mouse. Zinc chelate agent could attenuate eosinophilic airway inflammation in ovalbumin induced asthma model mouse, but it was not effective in mite antigen induced asthma model, which might be more similar to human asthma. Additionally, zinc chelate agent was not effective for the treatment of interstitial pneumonia model mouse.

Research Products

• [Journal Article] Differences in plasma and sputum biomarkers between COPD and COPD-asthma overlap (2013)
  • Author(s): Iwamoto H, Jing G, 他5名
  • Journal Title: Eur Respir J
  • Peer Reviewed
• [Journal Article] Characteristics of inspiratory and expiratory reactance in interstitial lung disease (2013)
  • Author(s): Sugiyama A, Hattori N, Haruta Y, Nakamura I, Nakagawa M, Miyamoto S, Onari Y, Iwamoto H, 他 4 名
  • Journal Title: Respir Med
  • Peer Reviewed
• [Journal Article] Miyamoto S, Hattori N, Senoo T, Onari Y, Iwamoto H, 他7 名 (2011)
  • Author(s): Miyamoto S, Hattori N, Senoo T, Onari Y, Iwamoto H, 他7 名
  • Journal Title: Am J Physiol Lung Cell Mol Physiol. Volume: 301(6)
  • Peer Reviewed
• [Journal Article] Erlotinib efficacy and cerebrospinal fluid concentration in patients with lung adenocarcinoma developing leptomeningeal metastases during gefitinib therapy (2011)
  • Author(s): Masuda T, Hattori N, Hamada A, Iwamoto H, 他7名
  • Journal Title: Cancer Chemother Pharmacol Volume: 67(6) Pages: 1465-9
  • Peer Reviewed
• [Journal Article] Regression of a primary pulmonary adenocarcinoma after zoledronic acid monotherapy (2011)
  • Author(s): Nagao S, Hattori N, Fujitaka K, Iwamoto H,他6 名
  • Journal Title: Hiroshima Journal of Medical Sciences Volume: 60(1) Pages: 7-9
  • NAID: 120005323956
  • Peer Reviewed
• [Presentation] Characteristics of inspiratory and expiratory reactance in interstitial lung disease (2012)
  • Author(s): Iwamoto H, Hattori N, 他10 名
  • Organizer: European respiratory society annual congress
  • Place of Presentation: ウィーン、オーストリア
  • Year and Date: 2012-09-04
• [Presentation] COPD と心血管疾患 (2010)
  • Author(s): 岩本博志
  • Organizer: 51回日本呼吸器学会総会 シンポジウム COPD の臨床的諸問題
  • Place of Presentation: 東京
  • Year and Date: 2010-04-23
• [Book] 合併症(全身併存症)心循環器疾患(特集COPD:診断と治療の進歩) (2012)
  • Author(s): 岩本博志、河野修興
  • Publisher: 日本内科学会雑誌