| Project/Area Number |
22790759
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
GOTO Hisatsugu 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (00437641)
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| Research Collaborator |
MITSUHASHI Atsushi 徳島大学, 大学院・学生医科学教育部, 医学専攻2年生
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 肺がん / サーファクタント / 肺サーファクタント蛋白 |
|---|
| Research Abstract |
Human SP-A gene was introduced into the human lung adenocarcinoma cell line, and in vivo effect of SP-A over-expression on cancer progression was examined in experimental mouse model. Lung tumor produced by SP-A over-expression cells had ; 1. less tumor burden and pleural effusion, 2. increased number of infiltrated macrophages, 3. increased number of M1 macrophages(anti-tumor macrophages). SP-A may have a protective role in lung cancer progression through modulating host immune response.
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