| Project/Area Number |
22790764
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Sapporo Medical University |
|---|
Principal Investigator |
ARIKI Shigeru 札幌医科大学, 医学部, 助教 (80464478)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
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| Keywords | 肺コレクチン / 自然免疫 / 細胞内寄生細菌 / レジオネラ |
|---|
| Research Abstract |
Pulmonary collectins play important roles in innate immunity of the lung. In this study, we found that pulmonary collectins attenuate autophagy induced by L. pneumophila infection. Furthermore, pulmonary collectins inhibit the secretion of effector molecules into host cells via type IV secretion system of L. pneumophila. These results suggest that pulmonary collectins protect host cells by the previously uncharacterized host defense mechanism against intracellular pathogen.
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