| Project/Area Number |
22790766
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 閉塞性肺疾患 / 気管支喘息 / MMP / iNOS / 慢性閉塞性肺疾患 / 肺線維芽細胞 / NF-κB / IRF-3 / リモデリング / 難治性喘息 / 気道リモデリング / テオフィリン / 窒素化ストレス / NF-kB / TGF-β1 / HDAC / TIMP / ステロイド抵抗性 |
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| Research Abstract |
Because it is well known that airway remodeling contributes to the refractoriness of asthma and MMPs play an important role in the formation of remodeling, we explored the factors that affect the production and activation of matrix metalloproteinase (MMPs) by lung fibroblast, one of the main producer of MMPs in the lung. We found that peroxynitrite, one of the potent oxidants, and activation of toll like receptor (TLR)-3 are the contributors of excessive MMP production and activation by lung fibroblasts. These results suggest that reactive nitrogen species and the TLR3 pathway are related with MMP-mediated airway remodeling.
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