| Project/Area Number |
22790768
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Juntendo University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
|---|
| Keywords | 肺胞マクロファージ / 喘息 / 補助シグナル分子 |
|---|
| Research Abstract |
Little is known about the population of alveolar macrophages(AM) from asthmatics. In the present study, we suggested that AM from a murine model of asthma transit towards an alternatively activated macrophages(M2) as compared with AM from control mice. Moreover, we found that AM from a murine model of asthma, but not from control mice, express the costimulatory molecule B7-DC, and AM might inhibit antigen-specific CD4 T cell proliferation. These findings suggest that AM can suppress the pathogenesis of asthma, and may be a novel therapeutic target in asthma.
|
