Analysis of hyperglycemia- and RAGE-induced allergic inflammation

• Project/Area Number: 22790769
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: Teikyo University
• Principal Investigator: SUZUKAWA Maho 帝京大学, 医学部, 助手 (20453699)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: アレルギー / 生活習慣病 / 糖尿病 / 気管支喘息 / RAGE / メタボリック症候群

Research Abstract

Advanced glycation end products (AGEs) are substances produced in high-glucose disease conditions and induce apoptosis and inflammatory cytokine secretion from human basophils. Human basophils express receptor for AGEs (RAGE). S100/A12 is another ligand for RAGE. S100/A12 induces airway inflammation in mice as well as upregulates inflammatory cytokine levels in bronchoalveolar lavage fluid in allergic mice.

Research Products

• [Journal Article] ORMDL-3 is an allergen inducible lung epithelial ER protein regulating metalloproteases, chemokines, OAS, and ATF6 (2012)
  • Author(s): Miller M, Tam A, Cho JY, Doherty T, Pham A, Khorram N, Rosenthal P, Mueller J, Hoffman H, Suzukawa M, Niwa M, Broide D
  • Journal Title: Proc Natl Acad Sci USA Volume: 109(41) Pages: 16648-53
  • Peer Reviewed
• [Journal Article] Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma (2012)
  • Author(s): Suzukawa M, Morita H, Nambu A, Arae K,Shimura E, Shibui A, Yamaguchi S, Suzukawa K, Nakanishi W, Oboki K, Kajiwara N, Ohno T, Ishii A, Korner H, Cua DJ, Suto H,Yoshimoto T, Iwakura Y, Yamasoba T, Ohta K, Sudo K, Saito H, Okumura K, Broide D,Matsumoto K, Nakae S
  • Journal Title: J Immunol Volume: 189(7) Pages: 3641-52
  • Peer Reviewed
• [Journal Article] 好塩基球脱顆粒反応が陽性であった豆腐、および大豆を原因とするアナフィラキシーの2例 (2012)
  • Author(s): 杉本 直也, 中瀬 裕子, 鈴川 真穂, 田下浩之, 新井 秀宜, 長瀬 洋之, 加藤 愛香, 山口 正雄, 大田 健
  • Journal Title: アレルギーの臨床 Volume: 32巻7号 Pages: 650-653
  • Peer Reviewed
• [Journal Article] ORMDL-3 is an allergen inducible lung epithelial ER protein regulating metalloproteases, chemokines, OAS, and ATF6. (2012)
  • Author(s): Miller M
  • Journal Title: Proc Natl Acad Sci USA Volume: 109(41) Issue: 41 Pages: 16648-53
  • DOI: 10.1073/pnas.1204151109
  • Peer Reviewed
• [Journal Article] Leptin enhances survival and induces migration, degranulation and cytokine synthesis of human basophils (2011)
  • Author(s): Suzukawa M, Nagase H, Ogahara I, Han K, Tashimo H, Shibui A, Koketsu R, Nakae S, Yamaguchi M, Ohta K
  • Journal Title: J Immunol Volume: 186(9) Pages: 5254-5260
  • Peer Reviewed
• [Journal Article] The in vitroeffects of advanced glycation end products on basophil functions (2011)
  • Author(s): Han K*, Suzukawa M* (* equally first authors), Yamaguchi M, Sugimoto N, Nakase Y, Toda T, Nagase H, Ohta K
  • Journal Title: Int Arch Allergy Immunol Volume: 155 Pages: 64-70
  • Peer Reviewed
• [Journal Article] A Case of Anaphylactic Reaction Following Matsutake Mushroom Ingestion: Demonstration of Histamine Release Reaction of Basophil (2011)
  • Author(s): Toda T, Yamaguchi M, Nakase Y, Sugimoto N, Suzukawa M, Nagase H, Ohta K
  • Journal Title: Allergol Int Volume: 59(4) Pages: 417-419
  • NAID: 10029671292
• [Journal Article] A Case of Anaphylactic Reaction Following Matsutake Mushroom Ingestion : Demonstration of Histamine Release Reaction of Basophils (2011)
  • Author(s): Takako Toda, Masao Yamaguchi, Yuko Nakase, Naoya Sugimoto, Maho Suzukawa, Hiroyuki Nagase, Ken Ohta
  • Journal Title: Allergology International Volume: 59(4) Pages: 417-419
  • NAID: 10029671292
  • Peer Reviewed
• [Presentation] The role of advanced glycation endproducts (AGEs) on basophil functions (2011)
  • Author(s): Maho Suaukawa, Masao Yamaguchi, Kaiyu Han, Takako Toda, Hiroyuki Nagase, Ken Ohta
  • Organizer: American Academy of Allergy Asthma & Immunology 2011 Annual meeting
  • Place of Presentation: サンフランシスコ
  • Year and Date: 2011-03-13
• [Presentation] マツタケによりアナフィラキシー症状を呈し、prick to prick testと好塩基球脱顆粒試験で陽性を示した1例 (2010)
  • Author(s): 戸田貴子, 原麻恵, 小島康弘, 竹澤智湖, 山村浩一, 鈴川真穂, 倉持美知雄, 田下浩之, 新井秀宜, 中野純一, 長瀬洋之, 山口正雄, 鈴木直仁
  • Organizer: 第22回日本アレルギー学会春季学術大会
  • Place of Presentation: 京都
• [Presentation] アトピー性皮膚炎乳児に対する乳酸菌製剤の有効性と免疫学的パラメーターの変化についての検討 (2010)
  • Author(s): 内山千登世(NTT東日本関東病院 小児科), 長瀬洋之, 鈴川真穂, 大田健, 斉藤恵美子, 岩田力, 渋谷紀子
  • Organizer: 第22回日本アレルギー学会春季学術大会
  • Place of Presentation: 京都
• [Presentation] シリカによる慢性肺線維化モデル確立のための長期検討 (2010)
  • Author(s): 原麻恵(帝京大学 内科呼吸器・アレルギー学), 長瀬洋之, 鈴川真穂, 小河原郁子, 戸田貴子, 小島康弘, 倉持美知雄, 田下浩之, 新井秀宜, 山口正雄, 鈴木直仁, 大田健
  • Organizer: 第50回日本呼吸器学会学術講演会
  • Place of Presentation: 京都
• [Presentation] 呼気一酸化窒素濃度(FeNO)の疾患特異性の検証 (2010)
  • Author(s): 戸田貴子(帝京大学 内科呼吸器・アレルギー学), 長瀬洋之, 原麻恵, 小河原郁子, 鈴川真穂, 小島康弘, 倉持美知雄, 田下浩之, 新井秀宜, 山口正雄, 鈴木直仁, 大田健
  • Organizer: 第50回日本呼吸器学会学術講演会
  • Place of Presentation: 京都
• [Presentation] Ken Ohta The role of advanced glycation endproducts (AGEs) on basophil functions
  • Author(s): Maho Suzukawa, Masao Yamaguchi, Kaiyu Han, Takako Toda, Hiroyuki Nagase
  • Organizer: American Academy of Allergy Asthma & Immunology 2011 Annual meeting
  • Place of Presentation: Washington DC, USA
• [Book] レプチンと好塩基球機能, 臨床免疫・アレルギー科58巻1号 (2012)
  • Author(s): 鈴川 真穂,大田 健
• [Book] レプチンと好塩基球機能 (2012)
  • Author(s): 鈴川 真穂
  • Total Pages: 6
  • Publisher: 科学評論社
• [Book] 咳喘息, 成人病と生活習慣病40巻11号 (2010)
  • Author(s): 鈴川 真穂,大田 健
• [Book] IL-33による好塩基球と好酸球の活性化, 臨床免疫・アレルギー科53巻1号 (2010)
  • Author(s): 鈴川 真穂,大田 健