| Project/Area Number |
22790771
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
HARA Hiromichi 東京慈恵会医科大学, 医学部, 助教 (70398791)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 慢性閉塞性肺疾患 / オートファジー / クレアチンキナーゼB(CKB) / CKB |
|---|
| Research Abstract |
We demonstrated the inhibitory role of autophagy in bronchial epithelial cell senescence induced by cigarette smoke extract(CSE) exposure. Although creatine kinase B(CKB) was not involved in regulation of autophagy function, decrease of CKB expression enhanced CSE-induced cellular senescence. Furthermore, CKB expression levels were reduced in bronchial epithelial cells isolated from COPD patients compared to those from non-smokers. Taken together, reduced CKB expression levels in lung may be involved in COPD pathogenesis through the acceleration of cellular senescence.
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