Regulatory analysis of DNA methylation in pulmonary fibrosis
| Project/Area Number |
22790772
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Kinki University |
|---|
Principal Investigator |
PARK Ah-mee 近畿大学, 医学部, 講師 (70469245)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | 肺線維化 / メチル化 / 筋線維芽細胞 / メチル化食 / 線維化 / DNMT3B / シリカ / DNAメチル化 / 転写因子 / プロモーター活性 |
|---|
| Research Abstract |
The object of this study is to clarify the epigenetic changes in pulmonary fibrosis. In vivo study using silica-induced mouse fibrosis model revealed that the DNA methylation level was unchanged, but the protein level of DNMT3B, which catalysis DNA methylation, was increased in fibrosis lung. In vitro study also showed the increase of this protein. The increase of DNMT3B protein may play important role in pulmonary fibrosis.
|
Report
(4 results)
Research Products
(18 results)
-
-
-
-
-
-
[Journal Article] The cancer stem cell marker CD133 is a predictor of the effectiveness of S1+ pegylated interferon-2b therapy against advanced hepatocellular carcinoma.2011
Author(s)
Hagiwara S, Kudo M, Ueshima K, Chung H, Yamaguchi M, Takita M, Haji S, Kimura M, Arao T, Nishio K, Park AM, Munakata H.
-
Journal Title
J Gastroenterol.
Volume: 46(2)
Issue: 2
Pages: 212-21
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
