Characterization of murine T cells that confer late asthmatic response

• Project/Area Number: 22790773
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital
• Principal Investigator: ABE Akemi 独立行政法人国立病院機構(相模原病院臨床研究センター), 先端技術開発研究部, 研究員 (20570667)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 気管支平滑筋細胞 / 遅発型喘息反応 / 閉塞性肺疾患 / T細胞 / アレルギー喘息 / 遅発性喘息反応

Research Abstract

Culture supernatants of anti-CD3 antibody-or anti-CD3/CD28 antibodies-activated but not resting murine Th clones that conferred a late asthmatic response, induced the contraction of human bronchial smooth muscle cell-containing collagen gels. These results indicate that activated Th cells produce a contractile activity for bronchial smooth muscle in vitro and have an important role to confer a late asthmatic response.

Research Products

• [Journal Article] Murine T cell-derived contractile activity for human bronchial smooth muscle cells (2012)
  • Author(s): Abe, A., Koyama, S., Ohtomo, T., Kitamura, N., Kaminuma, O., and Mori, A.
  • Journal Title: Int. Arch. Allergy Immunol Volume: 158 Issue: Suppl. 1 Pages: 7-10
  • DOI: 10.1159/000337743
  • Peer Reviewed
• [Journal Article] Comparative analysis of steroid sensitivity of Th cells in vitro and in vivo (2011)
  • Author(s): Abe A, Kaminuma O, et al
  • Journal Title: International Archives of Allegy and Immunology Volume: VOL.155 Issue: Suppl. 1 Pages: 110-116
  • DOI: 10.1159/000327494
  • Peer Reviewed
• [Journal Article] Comparative Analysis of Steroid Sensitivity of T Helper Cells in vitro and in vivo (2011)
  • Author(s): 安部暁美
  • Journal Title: International Archives of Allergy and Immunology Volume: 155(suppl 1) Pages: 110-116
  • Peer Reviewed
• [Presentation] Role of T cells in late phase asthmatic response (2011)
  • Author(s): Mori A, Kitamura N, Abe A, Ohtomo T, Kaminuma O.
  • Organizer: The 8th Asia Pacific Congress of Allergy, Asthma and Clinical Immunology
  • Place of Presentation: Singapore
  • Year and Date: 2011-11-07
• [Presentation] T cell clone transfer model for steroid resistant asthma (2011)
  • Author(s): Mori A, Abe A, Koyama S, Kitamura N, Yamaguchi M, Mitsui C, Oshikata C, Tanimoto H, Fukutomi Y, Sekiya K, Taniguchi M, Maeda Y, Ohtomo M, Hasegawa M, Akiyama K, Ohtomo T, Kaminuma O.
  • Organizer: European Respiratory Society Amsterdam 2011
  • Place of Presentation: Amsterdam, the Netherlands
  • Year and Date: 2011-09-25
• [Presentation] ヒト気管支平滑筋細胞ゲルを用いた気管支収縮因子の探索 (2011)
  • Author(s): 安部暁美、神山智、大友隆之、北村紀子、神沼修、森晶夫
  • Organizer: アレルギー・好酸球研究会2011
  • Place of Presentation: 大手町サンケイプラザ(東京)
  • Year and Date: 2011-06-18
• [Presentation] ヒト気管支平滑筋細胞ゲルを用いた気管支収縮因子の探索 (2011)
  • Author(s): 安部暁美
  • Organizer: アレルギー好酸球研究会2011
  • Place of Presentation: 大手町サンケイプラザ(東京)
  • Year and Date: 2011-06-18
• [Presentation] Comparative analysis of steroid sensitivity of Th cells in vitro and in vivo (2011)
  • Author(s): Mori A, Abe A, Koyama S, Kitamura N, Yamaguchi M, Tanimoto H, Sekiya K, Oshikata C, Mitsui C, Taniguchi M, Ohtomo M, Maeda Y, Hasegawa M, Akiyama K, Ohtomo T, Kaminuma O.
  • Organizer: 2011 European Academy of Allergy and Clinical Immunology
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2011-06-14
• [Presentation] T細胞クローン移入喘息モデルによるステロイド感受性解析 (2010)
  • Author(s): 安部暁美、大友隆之、神山智、北村紀子、神沼修、森晶夫
  • Organizer: アレルギー・好酸球研究会2010
  • Place of Presentation: 大手町サンケイプラザ(東京)
  • Year and Date: 2010-06-19
• [Presentation] T細胞クローン移入喘息モデルによるステロイド感受性解析 (2010)
  • Author(s): 安部暁美
  • Organizer: アレルギー好酸球研究会2010
  • Place of Presentation: 大手町サンケイプラザ(東京)
  • Year and Date: 2010-06-19
• [Presentation] T cell dependent bronchoconstriction in vivo and in vitro (2010)
  • Author(s): Mori A, Kitamura N, Ohtomo T, Abe A, Kaminuma O.
  • Organizer: 29th Congress of the European Academy of Allergy and Clinical Immunology
  • Place of Presentation: London, UK
  • Year and Date: 2010-06-08
• [Presentation] Analysis of T cell-dependent bronchoconstriction using human cultured bronchial smooth muscle cells (2010)
  • Author(s): Mori A, Kitamura N, Ohtomo T, Abe A, Kaminuma O.
  • Organizer: 28th Symposium of the Collegium International Allergologicum
  • Place of Presentation: Ischia, Italy
  • Year and Date: 2010-04-25