| Project/Area Number |
22790773
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital |
|---|
Principal Investigator |
ABE Akemi 独立行政法人国立病院機構(相模原病院臨床研究センター), 先端技術開発研究部, 研究員 (20570667)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 気管支平滑筋細胞 / 遅発型喘息反応 / 閉塞性肺疾患 / T細胞 / アレルギー喘息 / 遅発性喘息反応 |
|---|
| Research Abstract |
Culture supernatants of anti-CD3 antibody-or anti-CD3/CD28 antibodies-activated but not resting murine Th clones that conferred a late asthmatic response, induced the contraction of human bronchial smooth muscle cell-containing collagen gels. These results indicate that activated Th cells produce a contractile activity for bronchial smooth muscle in vitro and have an important role to confer a late asthmatic response.
|
