Development of SOCS gene therapy for malignant pleural mesothelioma

• Project/Area Number: 22790775
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: 独立行政法人医薬基盤研究所
• Principal Investigator: IWAHORI Kota 独立行政法人医薬基盤研究所, 創薬基盤研究部, 研究員 (80566448)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 悪性胸膜中皮腫 / 遺伝子治療 / SOCS / SOCS(Suppressor of cytokine signaling)

Research Abstract

In this study, we developed suppressor of cytokine signalling(SOCS) gene therapy, which targets multiple signaling, for the treatment of mesothelioma. Specifically, we demonstrated that SOCS gene delivery cooperates with cisplatin plus pemetrexed, the first line chemotherapy of this disease, to inhibit tumor growth of mesothelioma in vitro and in vivo. This study provides new insights into the clinical application of SOCS-1 gene therapy for the treatment of mesothelioma.

Research Products

• [Journal Article] Antiproliferative effect of SOCS-1 through the suppression of STAT3 and p38 MAPK activation in gastric cancer cells (2011)
  • Author(s): Souma Y, Nishida T, Serada S, Iwahori K, Takahashi T, Fujimoto M, Ripley B, Nakajima K, Miyazaki Y, Mori M, Doki Y, Sawa Y, Naka T
  • Journal Title: Int J Cancer Volume: (in press) Issue: 6 Pages: 1287-96
  • DOI: 10.1002/ijc.27350
  • Peer Reviewed
• [Journal Article] Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma (2011)
  • Author(s): Iwahori K, Serada S, Fujimoto M, Nomura S, Osaki T, Lee CM, Mizuguchi H, Takahashi T, Ripley B, Okumura M, Kawase I, Kishimoto T, Naka T
  • Journal Title: Int J Cancer Volume: 129(4) Issue: 4 Pages: 993-1005
  • DOI: 10.1002/ijc.25716
  • Peer Reviewed
• [Journal Article] Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma
  • Author(s): Iwahori K, et al.
  • Journal Title: International Journal of Cancer Volume: (In press)
  • Peer Reviewed
• [Presentation] SOCS1 gene delivery, in combination with pemetrexed and cisplatin treatment, enhances therapeutic efficacy in malignant mesothelioma (2011)
  • Author(s): Kota Iwahori, Satoshi Serada, Minoru Fujimoto, Hiroyuki Mizuguchi, Tetsuji Naka
  • Organizer: 第17回日本遺伝子治療学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2011-07-15
• [Presentation] SOCS-3 protein exhibits activity in malignant pleural mesothelioma (2010)
  • Author(s): Iwahori K, Serada S, Shimada K, Suzuki H, Hirashima T, Kawase I, Naka T
  • Organizer: The 10th International Conference of the International Mesothelioma Interest Group
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-09-02
• [Presentation] SOCS-3 protein exhibits preclinical anti-tumor activity in malignant pleural mesothelioma (2010)
  • Author(s): Iwahori K, et al.
  • Organizer: The 10th International Conference of the International Mesothelioma Interrest Group
  • Place of Presentation: 京都
  • Year and Date: 2010-09-02
• [Remarks]
  • URL: http://www.nibio.go.jp/news/2010/10/000033.html
• [Remarks]
  • URL: http://www.nibio.go.jp/news/2010/10/000033.html
• [Remarks]
  • URL: http://www.nibio.go.jp/news/2010/10/000033.html