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The role of Paraoxonase-1 in chronic kidney disease and renovascular injury

Research Project

Project/Area Number 22790777
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Kidney internal medicine
Research InstitutionYamagata University

Principal Investigator

ICHIKAWA Kazunobu  山形大学, 医学部, 助教 (50436218)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsParaoxonase-1 / 慢性腎臓病 / 遺伝子多型 / PON1 / CKD / 遺伝子多形 / SNPs
Research Abstract

We performed immunohistochemistry for PON1 in rat 5/6 nephrectomy model. It showed that PON1 expression in vascular endothelium was associated with renovascular injury. Then we examined the association of PON1 genotype (rs662) and prognosis among patients with end-stage renal disease. However, there was no significant difference between survival rate and PON1 genotype, suggesting that PON1 gene was not associated with the risk of cardiovascular disease and prognosis in end-stage renal disease.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (6 results)

All 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (2 results)

  • [Journal Article] Significance of past history of renal failure for the detection of high-risk individuals for cardiovascular and end-stage renal disease : analysis of data from a nationwide health checkup2011

    • Author(s)
      Ichikawa K, Konta T, Ikeda A, Fujimoto S, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Yoshida H, Asahi K, Kurahashi I, Ohashi Y, Watanabe T
    • Journal Title

      Clin Exp Nephrol

      Volume: 15(6) Issue: 6 Pages: 841-7

    • DOI

      10.1007/s10157-011-0509-y

    • NAID

      10030341666

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increases in urinary albumin and beta2-microglobulin are independently associated with blood pressure in the Japanese general population : the Takahata Study2011

    • Author(s)
      Mashima Y, Konta T, Kudo K, Takasaki S, Ichikawa K, Suzuki K, Shibata Y, Watanabe T, Kato T, Kawata S, Kubota I
    • Journal Title

      Hypertens Res

      Volume: 34(7) Issue: 7 Pages: 831-5

    • DOI

      10.1038/hr.2011.42

    • NAID

      10031163265

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphism of proinflammatory cytokine genes and albuminuria in the Japanese general population: the Takahata study2011

    • Author(s)
      Mashima Y, Konta T, Kudo K, Suzuki K, Ikeda A, Ichikawa K, Shibata Y, Watanabe T, Tamiya G, Kato T, Kawata S, Kubota I.
    • Journal Title

      Nephrol Dial Transplant

      Volume: 26(12) Issue: 12 Pages: 3902-3907

    • DOI

      10.1093/ndt/gfr105

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The association between renal tubular damage and rapid renal deterioration in the Japanese population : the Takahata study2011

    • Author(s)
      Kudo K, Konta T, Mashima Y, Ichikawa K, Takasaki S, Ikeda A, Hoshikawa M, Suzuki K, Shibata Y, Watanabe T, Kato T, Kawata S, Kubota I
    • Journal Title

      Clin Exp Nephrol

      Volume: 15(2) Issue: 2 Pages: 235-41

    • DOI

      10.1007/s10157-010-0392-y

    • NAID

      10029005241

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 透析患者におけるParaoxonase-1遺伝子多型と生命予後に関する検討2012

    • Author(s)
      市川一誠, 今田恒夫, 久保田功, 他
    • Organizer
      第56回日本透析医学会学術集会・総会
    • Place of Presentation
      横浜市パシフィコ横浜
    • Year and Date
      2012-06-07
    • Related Report
      2011 Final Research Report
  • [Presentation] 透析患者におけるParaoxonase-1遺伝子多型と生命予後に関する検討2011

    • Author(s)
      市川一誠
    • Organizer
      第54回日本透析医学会学術集会
    • Place of Presentation
      横浜市パシフィコ横浜
    • Year and Date
      2011-06-17
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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