The role of Paraoxonase-1 in chronic kidney disease and renovascular injury

• Project/Area Number: 22790777
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Kidney internal medicine
• Research Institution: Yamagata University
• Principal Investigator: ICHIKAWA Kazunobu 山形大学, 医学部, 助教 (50436218)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: Paraoxonase-1 / 慢性腎臓病 / 遺伝子多型 / PON1 / CKD / 遺伝子多形 / SNPs

Research Abstract

We performed immunohistochemistry for PON1 in rat 5/6 nephrectomy model. It showed that PON1 expression in vascular endothelium was associated with renovascular injury. Then we examined the association of PON1 genotype (rs662) and prognosis among patients with end-stage renal disease. However, there was no significant difference between survival rate and PON1 genotype, suggesting that PON1 gene was not associated with the risk of cardiovascular disease and prognosis in end-stage renal disease.

Research Products

• [Journal Article] Significance of past history of renal failure for the detection of high-risk individuals for cardiovascular and end-stage renal disease : analysis of data from a nationwide health checkup (2011)
  • Author(s): Ichikawa K, Konta T, Ikeda A, Fujimoto S, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Yoshida H, Asahi K, Kurahashi I, Ohashi Y, Watanabe T
  • Journal Title: Clin Exp Nephrol Volume: 15(6) Issue: 6 Pages: 841-7
  • DOI: 10.1007/s10157-011-0509-y
  • NAID: 10030341666
  • Peer Reviewed
• [Journal Article] Increases in urinary albumin and beta2-microglobulin are independently associated with blood pressure in the Japanese general population : the Takahata Study (2011)
  • Author(s): Mashima Y, Konta T, Kudo K, Takasaki S, Ichikawa K, Suzuki K, Shibata Y, Watanabe T, Kato T, Kawata S, Kubota I
  • Journal Title: Hypertens Res Volume: 34(7) Issue: 7 Pages: 831-5
  • DOI: 10.1038/hr.2011.42
  • NAID: 10031163265
  • Peer Reviewed
• [Journal Article] Polymorphism of proinflammatory cytokine genes and albuminuria in the Japanese general population: the Takahata study (2011)
  • Author(s): Mashima Y, Konta T, Kudo K, Suzuki K, Ikeda A, Ichikawa K, Shibata Y, Watanabe T, Tamiya G, Kato T, Kawata S, Kubota I.
  • Journal Title: Nephrol Dial Transplant Volume: 26(12) Issue: 12 Pages: 3902-3907
  • DOI: 10.1093/ndt/gfr105
  • Peer Reviewed
• [Journal Article] The association between renal tubular damage and rapid renal deterioration in the Japanese population : the Takahata study (2011)
  • Author(s): Kudo K, Konta T, Mashima Y, Ichikawa K, Takasaki S, Ikeda A, Hoshikawa M, Suzuki K, Shibata Y, Watanabe T, Kato T, Kawata S, Kubota I
  • Journal Title: Clin Exp Nephrol Volume: 15(2) Issue: 2 Pages: 235-41
  • DOI: 10.1007/s10157-010-0392-y
  • NAID: 10029005241
  • Peer Reviewed
• [Presentation] 透析患者におけるParaoxonase-1遺伝子多型と生命予後に関する検討 (2012)
  • Author(s): 市川一誠, 今田恒夫, 久保田功, 他
  • Organizer: 第56回日本透析医学会学術集会・総会
  • Place of Presentation: 横浜市パシフィコ横浜
  • Year and Date: 2012-06-07
• [Presentation] 透析患者におけるParaoxonase-1遺伝子多型と生命予後に関する検討 (2011)
  • Author(s): 市川一誠
  • Organizer: 第54回日本透析医学会学術集会
  • Place of Presentation: 横浜市パシフィコ横浜
  • Year and Date: 2011-06-17