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The relation between the pattern of urine proteome and renal parameters

Research Project

Project/Area Number 22790778
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Kidney internal medicine
Research InstitutionYamagata University

Principal Investigator

IKEDA Ami  山形大学, 医学部, 助教 (50536985)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords尿プロテオーム / 慢性腎臓病 / 腎予後マーカー / 一般住民
Research Abstract

To clarify the clinical utility of urine proteome in renal diseases, we investigate the relation between the pattern of urine proteome and renal parameters in health checkup participants and patients with renal diseases. The urine specimens of renal diseases showed the 0-8 peaks in proteome pattern and the number of proteome peak was increased along with the increase in urine protein excretion. The range of highest peak in proteome pattern was related with the renal histological changes. The 1-year decrease in estimated GFR (mL/min/1.73m^2) was larger in groups with 10-40k peakand 60-80k peak, compared with no peak group. The urine proteome pattern is related with renal parameters, and could be a useful renal index in clinical practice.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (5 results)

All 2011 2010

All Presentation (5 results)

  • [Presentation] The relation between the pattern of urine proteome and renal parameters2011

    • Author(s)
      池田亜美
    • Organizer
      ERA-EDTA(European Renal Association-European Dialysis and Transplant Association)
    • Place of Presentation
      プラハチェコスロバキア
    • Year and Date
      2011-06-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 尿プロテオームパターンと腎疾患指標との関連2011

    • Author(s)
      池田亜美
    • Organizer
      第54回日本腎臓学会学術総会
    • Place of Presentation
      横浜市パシフィコ横浜
    • Year and Date
      2011-06-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 尿プロテオームパターンと腎疾患指標との関連2011

    • Author(s)
      池田亜美
    • Organizer
      第54回日本腎臓学会総会学術総会
    • Place of Presentation
      横浜市パシフィコ横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] The relation between the pattern of urine proteome and renal parameters2011

    • Author(s)
      池田亜美
    • Organizer
      ERA-EDTA (European Renal Association-European Dialysis and Transplant Association)
    • Place of Presentation
      Prague(CZECH REP.)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腎臓病の診断と進行リスク評価における尿プロテオーム解析の有用性2010

    • Author(s)
      池田亜美
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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