Exploring the mechanism of the glomerular parietal epithelial cell proliferation in crescentic glomerulonephritis and its treatment

• Project/Area Number: 22790779
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Kidney internal medicine
• Research Institution: The University of Tokyo
• Principal Investigator: OHSE Takamoto 東京大学, 医学部附属病院, 助教 (10568447)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 糸球体壁細胞 / 半月体形成性腎炎 / 細胞増殖

Research Abstract

It was revealed that the proliferation of glomerular parietal epithelial cells was induced by collagen. The mechanistic study for this collagen induced proliferation is now being investigated with in vitro and in vivo(anti-GBM nephritis mouse model) models.

Research Products

• [Journal Article] Albumin-induced apoptosis of glomerular parietal epithelial cells is modulated by extracellular signal-regulated kinase 1/2 (2012)
  • Author(s): Chang AM, Ohse T, Krofft RD, Wu JS, Eddy AA, Pippin JW, Shankland SJ.
  • Journal Title: Nephrol Dial Transplant Volume: 27(4) Issue: 4 Pages: 1330-43
  • DOI: 10.1093/ndt/gfr483
  • Peer Reviewed
• [Presentation] 腎炎・ネフローゼ(基礎)(4)糸球体壁細胞(PEC)に発現する遺伝子のマイクロアレイ法による同定 (2011)
  • Author(s): 大瀬貴元
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-17
• [Presentation] 糸球体壁細胞(PEC)に発現する遺伝子のマイクロアレイ法による同定 (2011)
  • Author(s): 大瀬貴元
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-17
• [Presentation] シンポジウム3FSGSを上皮細胞のバイオロジーから考える糸球体壁細胞(PEC)から見たFSGS (2011)
  • Author(s): 大瀬貴元
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-16
• [Presentation] 糸球体壁細胞(PEC)から見たFSGS (2011)
  • Author(s): 大瀬貴元
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: 横浜(シンポジウム)(招待講演)
  • Year and Date: 2011-06-16
• [Presentation] ボウマン嚢上皮細胞(PEC)における実験腎炎モデルでのポドサイトタンパク質の発現 (2010)
  • Author(s): 大瀬貴元
  • Organizer: 第53回日本腎臓学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-17