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Evaluation of biomarkers in drug-induced acute kidney injury model

Research Project

Project/Area Number 22790780
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Kidney internal medicine
Research InstitutionThe University of Tokyo

Principal Investigator

NEGISHI Kosuke  東京大学, 医学部附属病院, 特任臨床医 (40572219)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords急性腎障害 / 薬剤性腎障害 / バイオマーカー / 脂肪酸結合蛋白 / ヨード造影剤 / 過酸化脂質
Research Abstract

I evaluated the utility of urine L-FABP for Acute kidney injury(AKI) biomarker in animal drug-induced renal injury models induced by radio-contrast(RC), gentamicin and vancomycin. In RC-induced AKI model, L-FABP was shed into the urine in a dose-dependent manner, and was demonstrated that hypoperfusion of peri-tubular capillary was one of the key factors to induce its renal expression and the elevation of its urinary shedding. Furthermore, it was confirmed that L-FABP was a useful biomarker that responded to RC sensitively. However, additional biomarker studies are needed for gentamicin and vancomycin-induced AKI. In future, it is expected that further biomarker studies would improve diagnostic accuracy of drug-induced renal injury.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (20 results)

All 2012 2011 2010

All Journal Article (9 results) (of which Peer Reviewed: 7 results) Presentation (7 results) Book (4 results)

  • [Journal Article] 2つの尿バイオマーカーの組み合わせが成人心臓手術後急性腎障害を予測する2012

    • Author(s)
      片桐大輔, 土井研人, 根岸康介, 他
    • Journal Title

      胸部外科年報(Ann Thorac Surg)

      Volume: 93 Issue: 2 Pages: 577-83

    • DOI

      10.1016/j.athoracsur.2011.10.048

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 混合集中治療室における新規急性腎障害バイオマーカーの検討2011

    • Author(s)
      土井研人, 根岸康介, 他
    • Journal Title

      救急医学(Crit Care Med)

      Volume: 39 Pages: 2464-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 急性腎障害におけるEndotoxin activity assay(EAA)および血漿Neutrophil gelatinase-associated lipocalin(NGAL)を用いたエンドトキシンショックの検出2011

    • Author(s)
      土井研人, 根岸康介, 他
    • Journal Title

      日本急性血液浄化学会雑誌

      Volume: 2 Pages: 92-96

    • NAID

      40022131408

    • URL

      http://jsbpcc.umin.jp/

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 薬剤に起因する急性腎障害2011

    • Author(s)
      根岸康介
    • Journal Title

      腎と透析

      Volume: 70 Pages: 367-72

    • URL

      http://www.tokyo-igakusha.co.jp/

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] 急性腎障害(特集腎臓学この一年の進歩)2011

    • Author(s)
      土井研人, 根岸康介, 野入英世
    • Journal Title

      日本腎臓学会誌

      Volume: 53 Pages: 18-24

    • URL

      http://www.jsn.or.jp/journal/

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] 混合集中治療室における新規急性腎障害バイオマーカーの検討2011

    • Author(s)
      土井研人, 根岸康介, 他
    • Journal Title

      救急医学

      Volume: 39 Issue: 11 Pages: 2464-9

    • DOI

      10.1097/ccm.0b013e318225761a

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 急性腎障害におけるEndotoxin activity assay (EAA)および血漿Neutrophil gelatinase-associated lipocalin (NGAL)を用いたエンドトキシンショックの検出2011

    • Author(s)
      土井研人, 根岸康介, 他
    • Journal Title

      日本急性血液浄化学会雑誌

      Volume: 2 Pages: 92-96

    • NAID

      40022131408

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 敗血症に伴う新規急性腎障害バイオマーカーとしての尿脂肪酸結合蛋白2010

    • Author(s)
      土井研人, 根岸康介, 他
    • Journal Title

      救急医学(Crit Care Med)

      Volume: 39 Issue: 10 Pages: 2037-42

    • DOI

      10.1097/ccm.0b013e3181eedac0

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 敗血症に伴う新規急性腎障害バイオマーカーとしての尿脂肪酸結合蛋白2010

    • Author(s)
      土井研人, 根岸康介, 他
    • Journal Title

      救急医学(クリティカル ケア メディシン)

      Volume: 39 Pages: 2037-42

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] マウス造影剤誘発AKIモデルでの腎皮膜下皮質の傍尿細管灌流低下は尿L型脂肪酸結合蛋白(L-FABP)と逆相関する2011

    • Author(s)
      根岸康介, 他
    • Organizer
      米国腎臓学会総会
    • Place of Presentation
      米国
    • Year and Date
      2011-11-12
    • Related Report
      2011 Final Research Report
  • [Presentation] マウス造影剤誘発AKIモデルでの腎皮膜下皮質の傍尿細管灌流低下は尿L型脂肪酸結合蛋白(L-FABP)と逆相関する2011

    • Author(s)
      根岸康介, 他
    • Organizer
      米国腎臓学会総会
    • Place of Presentation
      ペンシルバニア会議センター,米国
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウス造影剤誘発AKIモデルでの尿L型脂肪酸結合蛋白(L-FABP)と腎微小循環2011

    • Author(s)
      根岸康介, 他
    • Organizer
      日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-06-17
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] マウス造影剤腎障害における尿L-FABPと腎皮質傍尿細管血流速度の測定2011

    • Author(s)
      根岸康介, 他
    • Organizer
      国際腎臓学会
    • Place of Presentation
      カナダ,バンクーバー国際会議場
    • Year and Date
      2011-04-10
    • Related Report
      2011 Final Research Report
  • [Presentation] マウス造影剤腎障害における尿L-FABPと腎皮質傍尿細管血流速度の測定2011

    • Author(s)
      根岸康介
    • Organizer
      国際腎臓学会
    • Place of Presentation
      カナダ,バンクーバー
    • Year and Date
      2011-04-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウス造影剤AKIでの尿L型脂肪酸結合蛋白(L-FABP)と腎微小循環のモニタリング2010

    • Author(s)
      根岸康介, 他
    • Organizer
      米国腎臓学会総会
    • Place of Presentation
      米国
    • Year and Date
      2010-11-19
    • Related Report
      2011 Final Research Report
  • [Presentation] マウス造影剤AKIでの尿L型脂肪酸結合蛋白(L-FABP)による尿細管障害のモニタリング2010

    • Author(s)
      根岸康介, 他
    • Organizer
      日本腎臓学会学術総会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-06-16
    • Related Report
      2011 Final Research Report
  • [Book] CRRTポケットマニュアル2011

    • Author(s)
      野入英世,花房規男,根岸康介, 他
    • Total Pages
      240
    • Publisher
      医歯薬出版
    • Related Report
      2011 Final Research Report
  • [Book] CRRTポケットマニュアル2011

    • Author(s)
      野入英世, 花房規男, 根岸康介, 他
    • Total Pages
      240
    • Publisher
      医歯薬出版
    • Related Report
      2011 Annual Research Report
  • [Book] CRRTポケットマニュアル2011

    • Author(s)
      野入英世, 花房規男, 根岸康介, 他
    • Total Pages
      240
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2010 Annual Research Report
  • [Book] アフェレシス療法ポケットマニュアル2010

    • Author(s)
      野入英世,花房規男,根岸康介, 他
    • Total Pages
      286
    • Publisher
      医歯薬出版
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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