Clarification of suppressive effects of ONO-1301 on the progression of chronic kidney disease and its mechanisms
| Project/Area Number |
22790791
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Okayama University |
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Principal Investigator |
NASU Tatsuyo 岡山大学, 医学部, 客員研究員 (70572741)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 慢性腎臓病 / 腎線維化 / 糖尿病性腎症 / プロスタサイクリン / 線維化 / 炎症 / HGF / EMT / 炎症細胞 / TGF-β1 / 尿細管上皮細胞 |
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| Research Abstract |
The number of patients with chronic kidney disease(CKD) requiring dialysis therapy is increasing. ONO-1301 is a long-acting prostacyclin(PGI2) agonist and possesses thromboxane A2 synthase inhibitory effects. In the present study, therapeutic effects of ONO-1301 on tubulointerstitial injuries and diabetic nephropathy mediated via anti-fibrotic, anti-inflammatory and via inducing HGF, were observed, suggesting the potential of ONO-1301 in suppressing the progression of CKD.
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] A sustained-release prostacyclin analog ONO-1301 ameliorates tubulointerstitial alterations in a mouse obstructive nephropathy model2012
Author(s)
Nasu T, Kinomura M, Tanabe K, Yamasaki H, Htay SL, Saito D, Hinamoto N, Watatani H, Ujike H, Suzuki Y, Sugaya T, Sugiyama H, Sakai Y, Matsumoto K, Maeshima Y, Makino H
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Journal Title
Am J Physiol-Renal Physiol
Volume: 302巻(in press)
Related Report
Peer Reviewed
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