| Project/Area Number |
22790801
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
WASHIDA Naoki 慶應義塾大学, 医学部, 助教 (40468492)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 中皮細胞再生 / 中皮細胞移植 / 被嚢性腹膜硬化症 / 腹膜癒着防止 / 腹膜透析 / 腹膜中皮細胞再生 / 腹膜中皮細胞移植 |
|---|
| Research Abstract |
The Flk1/HBME-1positive cell, which might be specific to the peritoneal mesothelial cell, was given to sort out in differentiated cells derived from human iPS cells.
The encapusulating peritoneal sclerosis(EPS) model mice, coming from the immunodeficiency mice, were made by the intraperitoneal injection of Methylglyoxal.
The regenerative cells were transplanted at the density of1×10_5cell per day for five days in the abdominal cavities of the EPS model mice. The submesothelial thickening were compared between the cell-transplanted group and untransplanted group. In the result, the thickening did not significantly differ from between these groups. In this research, it was not proved that the regenerative cell transplantation into the peritoneal cavity was effective to EPS model mice.
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