Amelioration of AngiotensinII-induced salt-sensitive hypertension by L-FABP in proximal tubules

• Project/Area Number: 22790803
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Kidney internal medicine
• Research Institution: Juntendo University
• Principal Investigator: TANIFUJI Chiaki 順天堂大学, 医学部, 助教 (80449058)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: L-FABP / 食塩感受性高血圧 / レニン・アンジオテンシン系 / 酸化ストレス / レニン・アンギオテンシン系 / レニン-アンジオテンシン系

Research Abstract

Recent findings indicated that inappropriate activation of the intrarenal renin-angiotensin system(RAS) induces reactive oxygen species production, which may contribute to salt-sensitive hypertension. On the other hand, L-FABP is expressed in renal proximal tubules in humans and may play an endogenous antioxidant role. The present study is to examine the antioxidative effect of L-FABP on salt-sensitive hypertension. The present findings indicated that L-FABP in proximal tubules may protect against AngII-induced SSHT in combination with attenuation of intrarenal RAS activation, oxidative stress. Therefore, L-FABP of proximal tubules may play a pathological role in SSHT.