Antioxidative defense mechanism of DJ-1, parkinson's disease related gene
| Project/Area Number |
22790809
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Hokkaido University |
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Principal Investigator |
NIKI Takeshi 北海道大学, 大学院・農学研究院, 准教授 (90377193)
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| Co-Investigator(Renkei-kenkyūsha) |
NIKI Kazuko 北海道大学, 大学院・薬学研究院, 助教 (50447645)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 神経分子病態学 / 酸化ストレス / 活性酸素 / DJ-1 / パーキンソン病 |
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| Research Abstract |
DJ-1 has multiple functions, including anti-oxidative stress, and its dysfunction may be linked to the onset of Parkinson's disease. In previous study, we isolated compounds that bind to DJ-1. These compounds prevented oxidative stress-induced cell death via DJ-1. But the action mechanism of DJ-1 binding compounds is unknown. In this study, we examined the effects of compound B, a DJ-1 binding compound on Nrf2 transcriptional activity. Compound B facilitated the H2O2-induced Nrf2 transactivation. Additionally, protein stability of Nrf2 was improved by compound Bwith H2O2. We suggest that DJ-1 and its binding compound B protect against neuronal death through enhancement of oxidative stress-induced Nrf2 transactivation.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] A novel signaling pathway mediated by the nuclear targeting of C-terminal fragments of mammalian Patched 12011
Author(s)
Kagawa, H., Shino, Y., Kobayashi, D., Demizu, S., Shimada, M., Ariga, H., Kawahara, H.
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Journal Title
PLoS ONE
Volume: 6
Issue: 51
Pages: 39718-39731
DOI
Related Report
Peer Reviewed
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[Presentation] Oxidative stress-response by DJ-1 and its binding compounds2012
Author(s)
Niki, T., Takahashi-Niki, K., Okamoto, A., Endo, J., Ariga, H., Iguchi-Ariga, S. M. M.
Organizer
The 41th annual meeting of the Society for Neuroscience
Place of Presentation
Washington DC, USA
Year and Date
2012-11-12
Related Report
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