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Antioxidative defense mechanism of DJ-1, parkinson's disease related gene

Research Project

Project/Area Number 22790809
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionHokkaido University

Principal Investigator

NIKI Takeshi  北海道大学, 大学院・農学研究院, 准教授 (90377193)

Co-Investigator(Renkei-kenkyūsha) NIKI Kazuko  北海道大学, 大学院・薬学研究院, 助教 (50447645)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords神経分子病態学 / 酸化ストレス / 活性酸素 / DJ-1 / パーキンソン病
Research Abstract

DJ-1 has multiple functions, including anti-oxidative stress, and its dysfunction may be linked to the onset of Parkinson's disease. In previous study, we isolated compounds that bind to DJ-1. These compounds prevented oxidative stress-induced cell death via DJ-1. But the action mechanism of DJ-1 binding compounds is unknown. In this study, we examined the effects of compound B, a DJ-1 binding compound on Nrf2 transcriptional activity. Compound B facilitated the H2O2-induced Nrf2 transactivation. Additionally, protein stability of Nrf2 was improved by compound Bwith H2O2. We suggest that DJ-1 and its binding compound B protect against neuronal death through enhancement of oxidative stress-induced Nrf2 transactivation.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (12 results)

All 2012 2011 2010 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] Stimulation of vesicular monoamine transporter 2 activity by DJ-1 in SH-SY5Y cells Shizuma Ishikawa2012

    • Author(s)
      Yuki Tanaka, Kazuko Takahashi-Niki, Takeshi Niki, Hiroyoshi Arigab, Sanae M. M. Iguchi-Ariga
    • Journal Title

      Biochem. Biochemical and Biophysical Research

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel signaling pathway mediated by the nuclear targeting of C-terminal fragments of mammalian Patched 12011

    • Author(s)
      Kagawa, H., Shino, Y., Kobayashi, D., Demizu, S., Shimada, M., Ariga, H., Kawahara, H.
    • Journal Title

      PLoS ONE

      Volume: 6 Issue: 51 Pages: 39718-39731

    • DOI

      10.1074/jbc.m110.137034

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human DJ-1-specific transcriptional activation of tyrosine hydroxylase gene.2010

    • Author(s)
      石川静麻
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 285(51) Pages: 39718-39731

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Oxidative stress-response by DJ-1 and its binding compounds2012

    • Author(s)
      Niki, T., Takahashi-Niki, K., Okamoto, A., Endo, J., Ariga, H., Iguchi-Ariga, S. M. M.
    • Organizer
      The 41th annual meeting of the Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2012-11-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Oxidative stress-response by DJ-1 and its binding compounas2011

    • Author(s)
      仁木剛史
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      Walter E.Washington Convention Center(アメリカワシントンDC)
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] パーキンソン病原因遺伝子産物DJ-1とその結合化合物による酸化ストレス誘導Nrf2転写活性化能に対する影響2011

    • Author(s)
      仁木剛史、仁木(高橋)加寿子、岡本麻美、遠藤仁朗、瀬在和哉、有賀寛芳、有賀(井口)早苗
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2011-09-23
    • Related Report
      2011 Final Research Report
  • [Presentation] DJ-1の抗酸化ストレスセンサーとしての役割2011

    • Author(s)
      仁木(高橋)加寿子、仁木剛史、辻美咲、北浦廣剛、有賀(井口)早苗、有賀寛芳
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2011-09-23
    • Related Report
      2011 Final Research Report
  • [Presentation] バーキンソン病原因遺伝子産物DJ-1とその結合化合物による酸化ストレス誘導Nrf2転写活性化能に対する影響2011

    • Author(s)
      仁木剛史
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] パーキンソン病原因遺伝子産物DJ-1とその結合化合物による酸化ストレス応答2010

    • Author(s)
      仁木剛史
    • Organizer
      第33回日本分子生物学会年会・第88回日本生化学会大会 合同大会
    • Place of Presentation
      兵庫県神戸市中央区神戸国際展示場
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] パーキンソン病原因遺伝子DJ-1の抗酸化ストレス機能の解析2010

    • Author(s)
      仁木加寿子、仁木剛史、有賀(井口)早苗、有賀寛芳
    • Organizer
      BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] パーキンソン病原因遺伝子産物DJ-1とその結合化合物による酸化ストレス応答2010

    • Author(s)
      仁木剛史、仁木(高橋)加寿子、遠藤仁郎、瀬在和哉、岡本麻美、有賀寛芳、有賀(井口)早苗
    • Organizer
      BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸)
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.agr.hokudai.ac.jp/emolb/introduce.html

    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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