| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
To examine role of fatty acid signaling pathway on pathophysiology of vascular dementia, we examined expression analyses of Fabp7 in wild-type (WT)mice subjected to sham-and right unilateral common carotid artery occlusion (UCCAO). The results exhibited that there is no obvious difference of expression level and pattern of Fabp7 in the corpus callosum and the striatum in both sham-and UCCAO-operated mice. To examine contribution of Fabp7 on pathophysiology of vascular dementia, WT and Fabp7 knockout mice were subjected to sham-or right UCCAO. Obvious deficits e. g. body weight and neurological sign were not observed in both WT and Fabp7 knockout mice in the presence or absence of the surgery. Currently we examined histological analyses in the brain obtained from WT and Fabp7 knockout mice.
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