| Project/Area Number |
22790812
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Clinical research Center, Chiba-East National Hospital, National Hospital Organization (2011)
Chiba University (2010) |
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Principal Investigator |
ISOSE Sagiri 独立行政法人国立病院機構(千葉東病院臨床研究センター), 神経内科, 医師 (80466698)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 脳神経疾患 / 生理学 / 神経障害性疼痛 / 末梢神経障害 / 軸索機能検査法 / 軸索Na電流 |
|---|
| Research Abstract |
We investigated changes in nodal persistent Na^+currents in sensory axons of patients with neuropathic pain before and after mexiletine(Na^+channel blocker) administration, using computerized threshold tracking system. Mexiletine substantially suppressed the degree of pain associated with decreased Na^+currents. In addition, we established a recording of pain-related evoked potentials using intra-epidermal needle electrode which can selectively stimulate Aδand C fiber. The combination of evaluating peripheral ionic mechanism and studying central pathophysiology underlying neurpathic pain patients would contribute to establishment of an efficient therapeutic strategy in the future.
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