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Establishment of a therapeutic strategy based on axonal ionic pathophysiology in patients with neuropathic pain

Research Project

Project/Area Number 22790812
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionClinical research Center, Chiba-East National Hospital, National Hospital Organization (2011)
Chiba University (2010)

Principal Investigator

ISOSE Sagiri  独立行政法人国立病院機構(千葉東病院臨床研究センター), 神経内科, 医師 (80466698)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords脳神経疾患 / 生理学 / 神経障害性疼痛 / 末梢神経障害 / 軸索機能検査法 / 軸索Na電流
Research Abstract

We investigated changes in nodal persistent Na^+currents in sensory axons of patients with neuropathic pain before and after mexiletine(Na^+channel blocker) administration, using computerized threshold tracking system. Mexiletine substantially suppressed the degree of pain associated with decreased Na^+currents. In addition, we established a recording of pain-related evoked potentials using intra-epidermal needle electrode which can selectively stimulate Aδand C fiber. The combination of evaluating peripheral ionic mechanism and studying central pathophysiology underlying neurpathic pain patients would contribute to establishment of an efficient therapeutic strategy in the future.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (17 results)

All 2012 2011 2010

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (7 results)

  • [Journal Article] Differences in excitability between median and superficial radial sensory axons2012

    • Author(s)
      Fujimaki Y, Kanai K, Misawa S, Shibuya K, Isose S, Nasu S, Sekiguchi Y, Ohmori S, Noto YI, Kugio Y, Shimizu T, Matsubara S, Lin CS, Kuwabara S.
    • Journal Title

      Clin Neurophysiol

      Volume: 123(7) Pages: 1440-5

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/22204921

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered axonal excitability properties in juvenile muscular atrophy of distal upper extremity(Hirayama disease)2011

    • Author(s)
      Sawai S, Misawa S, Kanai K, Isose S, Shibuya K, Noto Y, Fujimaki Y, Sekiguchi Y, Nasu S, Nomura F, Kuwabara S.
    • Journal Title

      Clin Neurophysiol

      Volume: 122 Pages: 205-9

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/20624687

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] POEMS syndrome with Guillan-Barre syndrome-like acute onset : A case report and review of neurological progression in 30 cases2011

    • Author(s)
      Isose S, Misawa S, Kanai K, Shibuya K, Sekiguchi Y, Nasu S, Fujimaki Y, Noto Y, Nakaseko C, Kuwabara S.
    • Journal Title

      Journal of Neurology, Neurosurgery, and Psychiatry

      Volume: 82 Pages: 678-80

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/20562460

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differences in excitability between median and superficial radial sensory2011

    • Author(s)
      Fujimaki Y, Isose S, et al
    • Journal Title

      Clinical Neurophyisiology

      Volume: (inprinted)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered axonal excitability properties in juvenile muscular atrophy of distal upper extremity (Hirayama disease).2011

    • Author(s)
      Sawai S, Isose S, et al.
    • Journal Title

      Clin Neurophyisiol

      Volume: 122 Pages: 205-209

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distal motor axonal dysfunction in amyotrophic lateral sclerosis.2011

    • Author(s)
      Noto Y, Isose S, et al
    • Journal Title

      J Neurol Sci

      Volume: 15 Pages: 58-62

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term regular plasmapheresis as a maintenance treatment for chronic inflammatory demyelinating polyneuropathy2010

    • Author(s)
      Isose S, Mori M, Misawa S, Shibuya S, Kuwabara S.
    • Journal Title

      J Peripher Nerv Syst

      Volume: 15 Pages: 147-9

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/20626778

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mexiletine suppresses nodal persistent sodium currents in sensory axons of patients with neuropathic pain2010

    • Author(s)
      Isose S, Misawa S, Sakurai K, Kanai K, Shibuya K, Sekiguchi Y, Nasu S, Noto Y, Fujimaki Y, Yokote K, Kuwabara S.
    • Journal Title

      Clinical Neurophysiology

      Volume: 121(5) Pages: 719-24

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/20097124

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mexiletine suppresses nodal persistent sodium currents in sensory axons of patients with neuropathic pain2010

    • Author(s)
      Isose S, et al.
    • Journal Title

      Clin Neurophyisiol

      Volume: 121 Pages: 719-724

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term regular plasmapheresis as a maintenance treatment for chronic inflammatory demyelinating polyneuropathy.2010

    • Author(s)
      Isose S, et al
    • Journal Title

      J Peripher Nerv Syst

      Volume: 15 Pages: 147-149

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] CIDPの電気診断における遠位CMAP持続時間のピット・フォール2011

    • Author(s)
      磯瀬沙希里
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-05-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] 慢性炎症性脱髄性多発神経炎の臨床病型分類からみた治療反応性2011

    • Author(s)
      磯瀬沙希里
    • Organizer
      第23回日本末梢神経学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター
    • Related Report
      2011 Final Research Report
  • [Presentation] CIDPの電気診断における遠位CMAP持続時間のピット・フォール:低周波フィルターの影響2011

    • Author(s)
      磯瀬沙希里
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2011 Final Research Report
  • [Presentation] Mexiletine suppresses nodal persistent sodium currents in sensory axons of patients with neuropathic pain2010

    • Author(s)
      磯瀬沙希里
    • Organizer
      29th International Congress of Clinical Neurophysiology
    • Place of Presentation
      神戸国際会議場(神戸)
    • Year and Date
      2010-11-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mexiletine suppresses nodal persistent sodium currents in sensory axons of patients with neuropathic pain2010

    • Author(s)
      Sagiri Isose, Sonoko Misawa, Kenichi Sakurai, et al.(11名)
    • Organizer
      The 29th International Congress of Clinical Neurophysiology
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2011 Final Research Report
  • [Presentation] 再発性CIDPの長期寛解維持に間欠的血液浄化療法は有用である2010

    • Author(s)
      磯瀬沙希里
    • Organizer
      第28回日本神経治療学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] Crow-Fukase症候群における発症様式の多様性2010

    • Author(s)
      磯瀬沙希里
    • Organizer
      第51回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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