Novel neuroprotectant lithium in thrombolytic therapy

Research Project

Project/Area Number	22790813
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Neurology
Research Institution	Niigata University
Principal Investigator	TAKAHASHI Tetsuya 新潟大学, 医歯学総合病院, 助教 (20515663)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	脳塞栓モデル / リチウム / 神経保護 / Akt / 脳梗塞 / 血栓溶解療法 / 組織プラスミノゲンアクチベータ(t-PA)
Research Abstract	To investigate the neuroprotective effect of lithium with tissue plasminogen activator(t-PA) in thrombolytic therapy in stroke, I tried to establish the clinically-resembling animal stroke model. After several experimental condition had been tried, I've established the model that showed thrombolysis and neurological improvement by t-PA administration in early time point, and also showed worsened outcome including increased hemorrhage by t-PA administration in late time point. Similar animal model is not used in many reports because of the technical difficulty. Administration of lithium chloride after focal brain ischemia suppressed neurodegeneration through apoptosis. This protective effect was not related the activation of Akt.