| Project/Area Number |
22790814
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Niigata University |
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Principal Investigator |
YOKOSEKI Akio 新潟大学, 医歯学系, 特任准教授 (90515719)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ALS / TDP-43 / Cajal小体 / coilin / Coilin |
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| Research Abstract |
TAR DNA binding protein of 43 kDa(TDP-43) is a major protein of ubiquitinated cytoplasmic inclusions in glia and neurons in amyotrophic lateral sclerosis(ALS). TDP-43 has been reported to associate with nuclear bodies : Cajal bodies, GEM bodies, PML, and SC35. Therefore, we focused on Cajal bodies. The mean number of Cajal bodies in sporadic ALS cases was statistically decreased than that in controls. Cajal bodies play an important function as maturation of small nuclear and nucleolar ribonucleoproteins. Taken together, neuronal death may be caused by dysregulation of transcription in ALS motor neurons.
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