Search and identification of the genetic background for progression and prognosis in amyotrophic lateral sclerosis patients

• Project/Area Number: 22790817
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurology
• Research Institution: Nagoya University
• Principal Investigator: ATSUTA Naoki 名古屋大学, 医学部附属病院, 助教 (90547457)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 筋萎縮性側索硬化症 / 遺伝子多型 / 前向き臨床像 / 関連解析 / 一塩基多型

Research Abstract

To develop therapy for amyotrophic lateral sclerosis, identification of the disease-related genes and molecules is needed. I examined association between the large-scale prospective clinical information and the single nucleotide polymorphisms(SNPs) of the genomic genes in the ALS patient cohort. In the result, several SNPs had strong influences on survival duration or emergence of bulbar symptoms. Additional validations of this result are needed.

Research Products

• [Journal Article] Replication analysis of SNPs on 9p21. 2 and19p13. 3 with amyotrophic lateral sclerosis in East Asians (2011)
  • Author(s): Iida A, Takahashi A, Deng M, Zhang Y, Wang J, Atsuta N, Tanaka F, Kamei T, Sano M, Oshima S, Tokuda T, Morita M, Akimoto C, Nakajima M, Kubo M, Kamatani N, Nakano I, Sobue G, Nakamura Y, Fan D, Ikegawa S
  • Journal Title: Neurobiol Aging Volume: 32 : 757 Pages: 13-4
  • Peer Reviewed
• [Journal Article] High-Resolution Melting(HRM) Analysis of the Cu/Zn Superoxide Dismutase(SOD1) Gene in Japanese Sporadic Amyotrophic Lateral Sclerosis(SALS) Patients (2011)
  • Author(s): Akimoto C, Morita M, Atsuta N, Sobue G, Nakano I
  • Journal Title: Neurol Res Int Volume: 2011 Pages: 165415-165415
  • Peer Reviewed
• [Journal Article] JaCALS : a prospective multicenter ALS cohort study (2011)
  • Author(s): 熱田直樹、中村亮一、渡辺はづき、渡辺宏久、伊藤瑞規、千田譲、田中章景、祖父江元
  • Journal Title: 臨床神経学 Volume: 51 Pages: 903-5
  • NAID: 130004504908
• [Journal Article] 日本版ALSFRS-Rを用いた電話調査によるALS患者の評価広域的前向き縦断調査への応用BRAIN and NERVE (2011)
  • Author(s): 熱田直樹, 渡辺宏久, 伊藤瑞規, 中村亮一, 千田譲, 加藤重典, 祖父江元
  • Journal Title: 神経研究の進歩 Volume: 63巻5号 Pages: 491-496
  • Peer Reviewed
• [Journal Article] 日本版ALSFRS-Rを用いた電話調査によるALS患者の評価広域的前向き縦断調査への応用 (2011)
  • Author(s): 熱田直樹
  • Journal Title: BRAIN and NERVE:神経研究の進歩 Volume: 63 Pages: 491-496
  • NAID: 40018818165
  • Peer Reviewed
• [Journal Article] JaCALS : a prospective multicenter ALS cohort study (2011)
  • Author(s): 熱田直樹
  • Journal Title: 臨床神経学 Volume: 51 Pages: 903-905
  • NAID: 130004504908
• [Journal Article] 日本版ALSFRS-Rを用いた電話調査によるALS患者の評価-広域的前向き縦断調査への応用- (2011)
  • Author(s): 熱田直樹、渡辺宏久、伊藤瑞規、中村亮一、千田譲、加藤重典、祖父江元
  • Journal Title: BRAIN and NERVE-神経研究の進歩 Volume: (印刷中 未定)
  • NAID: 40018818165
  • Peer Reviewed
• [Journal Article] Japanese consortium for amyotrophic lateral sclerosis research(JaCALS) (2010)
  • Author(s): 熱田直樹、祖父江元
  • Journal Title: 臨床神経学 Volume: 50 Pages: 928-30
  • NAID: 130004504704
• [Journal Article] Clinicopathological features of acute autonomic and sensory neuropathy (2010)
  • Author(s): Koike H, Atsuta N, Adachi H, Iijima M, Katsuno M, Yasuda T, Fukada Y, Yasui K, Nakashima K, Horiuchi M, Shiomi K, Fukui K, Takashima S, Morita Y, Kuniyoshi K, Hasegawa Y, Toribe Y, Kajiura M, Takeshita S, Mukai E, Sobue G
  • Journal Title: Brain Volume: 133 Pages: 288-96
  • NAID: 10025625514
  • Peer Reviewed
• [Presentation] ALSの進行、予後規定因子 (2011)
  • Author(s): 熱田直樹、JaCALS
  • Organizer: 第52回日本神経学会学術大会シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2011-05-19
• [Presentation] JaCALS : ALSの進行、予後規定因子 (2011)
  • Author(s): 熱田直樹
  • Organizer: 第52回日本神経学会学術大会シンポジウム
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-05-19
• [Presentation] Japanese Consortium for Amyotrophic Lateral Sclerosis Research(JaCALS) (2010)
  • Author(s): 熱田直樹
  • Organizer: Workshop Recent advance in motor neuron disease research
  • Place of Presentation: 和光市RIKEN BSI
  • Year and Date: 2010-08-30
• [Presentation] Japanese Consortium for Amyotrophic Lateral Sclerosis Research(JaCALS) (2010)
  • Author(s): 熱田直樹
  • Organizer: 第51回日本神経学会総会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2010-05-22
• [Presentation] 上位運動ニューロン症候を呈さないALSの臨床病理学的特徴 (2010)
  • Author(s): 熱田直樹
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-20
• [Presentation] Japanese Consortium for Amyotrophic Lateral Sclerosis Research (JaCALS) (2010)
  • Author(s): 熱田直樹、祖父江元
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-05-20
• [Presentation] 上位運動ニューロン症候を呈さないALSの臨床病理学的特徴 (2010)
  • Author(s): 熱田直樹、吉田眞理、渡辺宏久、伊藤瑞規、千田譲、加賀友継、加藤重典、田中章景、橋詰良夫、祖父江元
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-05-18