Cellular stress by proteins contaminated with D-serine as a novel therapeutic target of amyotrophic lateral sclerosis
| Project/Area Number |
22790828
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Keio University |
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Principal Investigator |
SASABE Jumpei 慶應義塾大学, 医学部, 助教 (10398612)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | D-アミノ酸 / D-tyr-tRNA deacylase / D-セリン / 筋萎縮性側索硬化症 / D-Tyr-tRNA deacylase |
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| Research Abstract |
We investigated in this study how motoneurons reacts against contamination of D-amino acids in protein synthesis by focusing on D-tyr-tRNA deacylase(DTD). D-amino acids do not make any cellular stresses in the existence of DTD, whereas genetic disruption of DTD enhances unfolded protein response and D-amino acids increase ubiquitinated proteins.
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Report
(3 results)
Research Products
(22 results)
