• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Developing a new diagnostic system using positron emission tomography for dementia with Lewy bodies

Research Project

Project/Area Number 22790836
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

SHIMADA Hitoshi  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (10422239)

Co-Investigator(Renkei-kenkyūsha) SUHARA Tetsuya  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, プログラムリーダー (90216490)
SHINOTOH Hitoshi  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 上席研究員 (90226150)
HIGUCHI Makoto  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダー (10373359)
HIRANO Shigeki  千葉大学, 医学部附属病院, 助教 (60375756)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords神経機能画像学 / PET / 認知症 / レヴィ小体型認知症 / 鑑別診断
Research Abstract

We confirmed that positron emission tomography (PET) measurement of brain acetylcholinesterase activity in precuneus is useful for the differential diagnosis between dementia with Lewy bodies (DLB) and Alzheimer’s disease. As a result, we have established an new diagnostic system using PET for DLB.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (23 results)

All 2013 2012 2011

All Journal Article (6 results) (of which Peer Reviewed: 2 results) Presentation (17 results) (of which Invited: 4 results)

  • [Journal Article] Molecular imaging of dementia2012

    • Author(s)
      Mori T, Maeda J, Shimada H, Higuchi M, Shinotoh H, Ueno S, Suhara T
    • Journal Title

      Psychogeriatrics

      Volume: 12(2) Issue: 2 Pages: 106-114

    • DOI

      10.1111/j.1479-8301.2012.00409.x

    • NAID

      10029785231

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional brain imaging of cognitive dysfunction in Parkinson's disease2012

    • Author(s)
      Hirano Shigeki, Shinotoh Hitoshi
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 83(10) Pages: 963-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] コリン作動性シナプスのイメージング2012

    • Author(s)
      篠遠仁
    • Journal Title

      ClinicalNeuroscience

      Volume: 30(6) Pages: 675-678

    • Related Report
      2012 Final Research Report
  • [Journal Article] 認知症のバイオマーカーイメージング2012

    • Author(s)
      樋口真人
    • Journal Title

      Cognition and Dementia

      Volume: 12(1) Pages: 34-40

    • Related Report
      2012 Final Research Report
  • [Journal Article] 画像・バイオマーカーによるアルツハイマー病の早期診断2012

    • Author(s)
      樋口真人
    • Journal Title

      カレントテラピー[別冊]

      Volume: 30(4) Pages: 22-29

    • Related Report
      2012 Final Research Report
  • [Journal Article] 図説:精神疾患の脳イメージング2012

    • Author(s)
      藤原 広臨, 須原 哲也
    • Journal Title

      日本臨牀

      Volume: 70(1) Pages: 2-6

    • Related Report
      2012 Final Research Report
  • [Presentation] その治療の意義、語れますか?~分子イメージングが紡ぐ認知症治療戦略~.2013

    • Author(s)
      島田斉
    • Organizer
      愛宕認知症カンファレンス
    • Place of Presentation
      第一ホテル東京(東京都)
    • Year and Date
      2013-05-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Dementia with Lewy bodies can be well-differentiated from Alzheimer's disease by measurement of brain acetylcholinesterase activity by PET2013

    • Author(s)
      Shimada Hitoshi
    • Organizer
      THE 11th INTERNATIONAL CONFERENCE ON ALZHEIMER'S AND PARKINSON'S DISEASES
    • Place of Presentation
      Firenze Fiera Congress and Exhibition Center, Florence, Italy
    • Year and Date
      2013-03-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Dementia with Lewy bodies can be well-differentiated from Alzheimer‘s disease by measurement of brain acetylcholinesterase activity by PET2013

    • Author(s)
      島田 斉
    • Organizer
      THE 11th INTERNATIONAL CONFERENCE ON ALZHEIMER'S AND PARKINSON'S DISEASES
    • Place of Presentation
      Firenze Fiera Congress and Exhibition Center, Florence, Italy
    • Related Report
      2012 Annual Research Report
  • [Presentation] Molecular imaging systematics of the neurodegenerative dementia2012

    • Author(s)
      島田斉
    • Organizer
      震災復興分子イメージング国際シンポジウム「神経変性疾患の分子イメージング:その将来展望」
    • Place of Presentation
      東北大学艮陵会館(宮城県)
    • Year and Date
      2012-10-04
    • Related Report
      2012 Final Research Report
  • [Presentation] 日常診療を変える認知症画像研究の最先端2012

    • Author(s)
      島田斉
    • Organizer
      第3回 Chiba Dementia Conference
    • Place of Presentation
      ホテル・ザ・マンハッタン(千葉県)
    • Year and Date
      2012-09-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 認知症/糖尿病連関と分子イメージング2012

    • Author(s)
      島田斉
    • Organizer
      認知症と糖尿病について考える会
    • Place of Presentation
      京成ホテルミラマーレ(千葉県)
    • Year and Date
      2012-08-09
    • Related Report
      2012 Final Research Report
  • [Presentation] 分子イメージング研究が紡ぐ認知症治療戦略2012

    • Author(s)
      島田斉
    • Organizer
      CHIBA Geriatrics and Metabolism Seminar
    • Place of Presentation
      京成ホテルミラマーレ(千葉県)
    • Year and Date
      2012-04-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Molecular imaging systematics of the neurodegenerative dementia2012

    • Author(s)
      島田 斉
    • Organizer
      震災復興分子イメージング国際シンポジウム「神経変性疾患の分子イメージング:その将来展望」
    • Place of Presentation
      東北大学艮陵会館, 宮城
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 日常診療を変える認知症画像研究の最先端2012

    • Author(s)
      島田 斉
    • Organizer
      第3回 Chiba Dementia Conference
    • Place of Presentation
      ホテル・ザ・マンハッタン, 千葉
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 認知症/糖尿病連関と分子イメージング2012

    • Author(s)
      島田 斉
    • Organizer
      認知症と糖尿病について考える会
    • Place of Presentation
      京成ホテルミラマーレ, 千葉
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 分子イメージング研究が紡ぐ認知症治療戦略2012

    • Author(s)
      島田 斉
    • Organizer
      CHIBA Geriatrics and Metabolism Seminar
    • Place of Presentation
      京成ホテルミラマーレ, 千葉
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Dementia with Lewy bodies can be well-differentiated from Alzheimer's disease by measurement of brain acetylcholinesterase activity by PET2011

    • Author(s)
      Shimada Hitoshi
    • Organizer
      19th World Congress on Parkinson's disease and Related Disorders
    • Place of Presentation
      the Shanghai International Convention Center (中国)
    • Year and Date
      2011-12-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Dementia with Lewy bodies can be well-differentiated from Alzheimer's disease by measurement of brain acetylcholinesterase activity by PET2011

    • Author(s)
      島田斉
    • Organizer
      19th World Congress on Parkinson's disease and Related Disorders
    • Place of Presentation
      the Shanghai International Convention Center(中国)
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] PETによる脳内アセチルコリンエステラーゼ活性測定はアルツハイマー病とレヴィ小体型認知症をよく弁別する2011

    • Author(s)
      島田斉
    • Organizer
      第5回パーキンソン病運動障害疾患コングレス
    • Place of Presentation
      品川プリンスホテル(東京都)
    • Year and Date
      2011-10-08
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 脳内コリン神経系の障害はアルツハイマー病よりもレヴィ小体型認知症で重度である2011

    • Author(s)
      島田斉
    • Organizer
      第34回日本神経科学大会 / Neuroscience2011
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-09-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 脳内コリン神経系の障害はアルツハイマー病よりもレヴィ小体型認知症で重度である2011

    • Author(s)
      島田斉
    • Organizer
      第34回日本神経科学大会/Neuroscience2011
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dementia with Lewy bodies can be well-differentiated from Alzheimer's disease by measurement of brain acetylcholinesterase activity by PET2011

    • Author(s)
      島田斉
    • Organizer
      第52回神経学会学術大会
    • Place of Presentation
      名古屋国際会議場(三重県)
    • Year and Date
      2011-05-18
    • Related Report
      2012 Final Research Report 2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi