The role of mitochondrial dysfunction and mitophagy in the cellular model of familial Parkinson's disease.
Project/Area Number |
22790841
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Neurology
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Research Institution | 防衛大学校 |
Principal Investigator |
AMO Taku 防衛大学校, 応用科学群, 助教 (40453922)
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Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | パーキンソン病 / ミトコンドリア |
Research Abstract |
In PINK1-deficient mouse embryonic fibroblasts(MEFs), mitochondrial membrane potential and cellular ATP levels were decreased compared with those in littermate wild-type MEFs. However, mitochondrial proton leak, which reduces membrane potential in the absence of ATP synthesis, was not altered by loss of PINK1.Instead, activity of the respiratory chain, which produces the membrane potential by oxidizing substrates using oxygen, declined.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] Caloric restriction primes mitochondria for ischemic stress by deacetylating specific mitochondrial proteins of the electron transport chain.2011
Author(s)
Shinmura K, Tamaki K, Sano M, Nakashima-Kamimura N, Alexander MW, Amo T, Ota S, Katsumata Y, Fukuda K, Ishiwata K, Suematsu M, Adachi T.
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Journal Title
Circ Res
Volume: 109(4)
Issue: 4
Pages: 396-406
DOI
Related Report
Peer Reviewed
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[Presentation] Modular kinetic analysis as a powerful tool for investigation of mitochondrial bioenergetics2011
Author(s)
Amo T, Sato S, Saiki S, Kikusato M, Kawabata Y, Toyomizu M, Gautier C, Shen J, Ohta S, Hattori N, Brand MD
Organizer
第5回アジア酸化ストレス学会年会・第8回アジアミトコンドリア学会年会・第11回日本ミトコンドリア学会年会合同大会
Place of Presentation
鹿児島市民文化ホール(鹿児島県)
Year and Date
2011-09-02
Related Report
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[Presentation] Caloric restriction primes mitochondria for ischemic stress by deacetylating mitochondrial proteins2010
Author(s)
Shinmura K, Yae K, Tamaki K, Sano M, Katsumata Y, Ishiwata K, Adachi T, Kamimura N, Wolf AM, Amo T, Ohta S.
Organizer
第1回Molecular Cardiovascular Conference II
Place of Presentation
キロロ(北海道)
Year and Date
2010-09-04
Related Report
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[Presentation] Caloric restriction primes mitochondria for ischemic stress by deacetylating mitochondrial proteins.2010
Author(s)
Shinmura K, Yae K, Tamaki K, Sano M, Katsumata Y, Ishiwata K, Adachi T, Kamimura N, Wolf AM, Amo T, Ohta S.
Organizer
第1回 Molecular Cardiovascular Conference II
Place of Presentation
キロロ ホテルピアノ(北海道)
Year and Date
2010-09-04
Related Report
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