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The role of proton-sensing G protein coupled receptor in bone remodeling

Research Project

Project/Area Number 22790844
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Metabolomics
Research InstitutionGunma University

Principal Investigator

MOGI Chihiro  群馬大学, 生体調節研究所, 助教 (00375528)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords細胞・組織 / シグナル伝達 / 生理活性 / 生理学 / 生体分子 / 骨代謝 / PH / Gタンパク質共役型受容体 / pH
Research Abstract

It is well known that extracellular pH plays important roles in bone remodeling, but the molecular mechanisms are yet unidentified. To reveal the roles of novel four proton-sensing receptors (OGR1, GPR4, TDAG8, G2A), we assessed the bone mineral density and histology in pH-receptor knockout mice. These results suggested the relationship between OGR1 family and bone metabolism.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (29 results)

All 2012 2011 2010 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (12 results) Remarks (3 results)

  • [Journal Article] Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo2012

    • Author(s)
      Komachi M, Sato K, Tobo M, Mogi C, Yamada T, Ohta H, Tomura H, Kimura T, Im DS, Yanagida K, Ishii S, Takeyoshi I, Okajima F.
    • Journal Title

      Cancer Sci

      Volume: in press

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] An orally active lysophosphatidic acid receptor antagonist attenuates panereatic cancer invasion and metastasis in vivo2012

    • Author(s)
      Komachi M
    • Journal Title

      Cancer Science

      Volume: (印刷中) Issue: 6 Pages: 1099-1104

    • DOI

      10.1111/j.1349-7006.2012.02246.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of proton-sensing receptor TDAG8 in the anti-inflammatory actions of dexamethasone in peritoneal macrophages2011

    • Author(s)
      He XD, Tobo M, Mogi C, Nakakura T, Komachi M, Murata N, Takano M, Tomura H, Sato K, Okajima F.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 415(4) Pages: 627-31

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Extracellular acidification induces connective tissue growth factor production through proton-sensing receptor OGR1 in human airway smooth muscle cells2011

    • Author(s)
      Matsuzaki S, Ishizuka T, Yamada H, Kamide Y, Hisada T, Ichimonji I, Aoki H, Yatomi M, Komachi M, Tsurumaki H, Ono A, Koga Y, Dobashi K, Mogi C, Sato K, Tomura H, Mori M, Okajima F.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 413(4) Pages: 499-503

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of proton-sensing receptor TDAG8 in the anti-inflammatory actions of dexamethasone in peritoneal macrophages2011

    • Author(s)
      Xiao-Dong He
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 415 Issue: 4 Pages: 627

    • DOI

      10.1016/j.bbrc.2011.10.122

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extracellular acidification induces connective tissue growth factor production through proton-sensing receptor OGR1 in human airway smooth musele cells2011

    • Author(s)
      Matsuzaki S
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 413 Issue: 4 Pages: 499-503

    • DOI

      10.1016/j.bbrc.2011.08.087

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extracellular acidification stimulates IL-6 production and Ca(2+) mobilization through proton-sensing OGR1 receptors in human airway smooth muscle cells2010

    • Author(s)
      Ichimonji I, Tomura H, Mogi C, Sato K, Aoki H, Hisada T, Dobashi K, Ishizuka T, Mori M, Okajima F.
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol

      Volume: 299(4)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] protein-coupled receptor 1-dependent and-independent vascular actions to acidic pH in human aortic smooth muscle cells2010

    • Author(s)
      Liu JP, Komachi M, Tomura H, Mogi C, Damirin A, Tobo M, Takano M, Nochi H, Tamoto K, Sato K, Okajima F. Ovarian cancer G
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 299(3)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 細胞外pH環境を感知するプロトン感知性GPCRの機能と作用機構2010

    • Author(s)
      戸村秀明, 茂木千尋, 佐藤幸市, 岡島史和
    • Journal Title

      日本薬理学雑誌

      Volume: 135 Pages: 240-244

    • NAID

      10026544223

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways2010

    • Author(s)
      Liu JP, Nakakura T, Tomura H, Tobo M, Mogi C, Wang JQ, He XD, Takano M, Damirin A, Komachi M, Sato K, Okajima F.
    • Journal Title

      Pharmacol Res

      Volume: 61(6)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways.2010

    • Author(s)
      Liu JP, Nakakura T, Tomura H, Tobo M, Mogi C, Wang JQ, He XD, Takano M, Damirin A, Komachi M, Sato K, Okajima F.
    • Journal Title

      Pharmacol Res.

      Volume: 61 Pages: 499-505

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 細胞外pH環境を感知するプロトン感知性GPCRの機能を作用機構2010

    • Author(s)
      戸村秀明、茂木千尋、佐藤幸市、岡島史和
    • Journal Title

      日本薬理学雑誌

      Volume: 135 Pages: 240-244

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ovarian cancer G protein-coupled receptor 1-dependent and -independentvascular actions to acidic pH in human aortic smooth muscle cells.2010

    • Author(s)
      Liu JP, Komachi M, Tomura H, Mogi C, Damirin A, Tobo M, Takano M, Nochi H, Tamoto K, Sato K, Okajima F.
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: 299 Pages: 731-742

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extracellular acidification stimulates IL-6 production and Ca(^<2+>) mobilization through proton-sensing OGR1 receptors in human airway smooth muscle cells.2010

    • Author(s)
      Ichimonji I, Tomura H, Mogi C, Sato K, Aoki H, Hisada T, Dobashi K, Ishizuka T, Mori M, Okajima F.
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol.

      Volume: 299 Pages: 567-577

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] プロトン受容体OGR1の喘息における役割2012

    • Author(s)
      茂木千尋, 青木悠, 石塚全, 岡島史和
    • Organizer
      日本薬学会第132回年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] プロトン受容体OGR1の喘息における役割2012

    • Author(s)
      茂木千尋
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(札幌)
    • Related Report
      2011 Annual Research Report
  • [Presentation] プロトン感知性Gタンパク質共役型受容体OGR1の気管支喘息における関与について2011

    • Author(s)
      青木悠
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪国際館パミール(東京)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血漿ならびにリポ蛋白質HDL中スフィンゴシン1-リン酸濃度調節におけるABCA1トランスポーターの役割2011

    • Author(s)
      佐藤幸市
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2011 Annual Research Report
  • [Presentation] プロトン感知性OGR1を介したインスリン分泌調節メカニズム2011

    • Author(s)
      中倉敬
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2011 Annual Research Report
  • [Presentation] 細胞外プロトンをセンスするGタンパク共役型受容体の情報変換機構と生体機能2010

    • Author(s)
      戸村秀明, 茂木千尋, 当房雅之, 佐藤幸市, 岡島史和
    • Organizer
      第52回日本脂質生化学会
    • Place of Presentation
      群馬県伊香保
    • Year and Date
      2010-06-14
    • Related Report
      2011 Final Research Report
  • [Presentation] 細胞外プロトンをセンスするGタンパク共役型受容体の情報交換機構と生体機能2010

    • Author(s)
      戸村秀明、茂木千尋、当房雅之、佐藤幸市、岡島史和
    • Organizer
      第52回日本脂質生化学会
    • Place of Presentation
      伊香保
    • Related Report
      2010 Annual Research Report
  • [Presentation] インスリン分泌における細胞外pHの影響とOGR1の役割2010

    • Author(s)
      中倉敬、茂木千尋、戸村秀明、岡島史和
    • Organizer
      BMB2010(第33回日本分子生物学会年会、第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖質コルチコイドの抗炎症作用におけるTDAG8の役割2010

    • Author(s)
      Xiaodong He、当房雅之、茂木千尋、佐藤幸市、戸村秀明、岡島史和
    • Organizer
      BMB2010(第33回日本分子生物学会年会、第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト膵臓癌細胞株のインビボ転移・浸潤に対するリゾホスファチジン酸受容体アンタゴニストKi16198の抑制作用2010

    • Author(s)
      小町麻由美、佐藤幸市、茂木千尋、当房雅之、山田敬之、戸村秀明、岡島史和
    • Organizer
      BMB2010(第33回日本分子生物学会年会、第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] インスリン分泌調節における細胞外pHの影響とpH感知性GPCRの関与2010

    • Author(s)
      中倉敬、茂木千尋、戸村秀明、岡島史和
    • Organizer
      第35回日本比較内分泌学会大会
    • Place of Presentation
      静岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] Improving of experimental allergic asthma by decreased Th2 responses in OGR-1 knockout mice2010

    • Author(s)
      H.Aoki, C.Mogi, T.Hisada, T.Ishizuka, M.Utsugi, Y.Koga, A.Ono, K.Dobashi, M.Mori, F.Okajima
    • Organizer
      ERS 2010
    • Place of Presentation
      Barcelona (Spain)
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.imcr.gunma-u.ac.jp/lab/sigtra/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://imcr.showa.gunma-u.ac.jp/lab/signal/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.imcr.gunma-u.ac.jp/lab/sigtra/

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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