| Project/Area Number |
22790844
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Gunma University |
|---|
Principal Investigator |
MOGI Chihiro 群馬大学, 生体調節研究所, 助教 (00375528)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 細胞・組織 / シグナル伝達 / 生理活性 / 生理学 / 生体分子 / 骨代謝 / PH / Gタンパク質共役型受容体 / pH |
|---|
| Research Abstract |
It is well known that extracellular pH plays important roles in bone remodeling, but the molecular mechanisms are yet unidentified. To reveal the roles of novel four proton-sensing receptors (OGR1, GPR4, TDAG8, G2A), we assessed the bone mineral density and histology in pH-receptor knockout mice. These results suggested the relationship between OGR1 family and bone metabolism.
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