Analysis of the physiological roles of PHF2/ARID5B, a novel fasting-responsive transcription complex

Research Project

Project/Area Number	22790848
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Metabolomics
Research Institution	The University of Tokyo
Principal Investigator	OKUNO Yosuke 東京大学, 分子細胞生物学研究所, 特任研究員 (10534513)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	転写 / 発現制御 / 代謝
Research Abstract	To elucidate the role of PHF2 in vivo, we have generated systemic PHF2 knockout mice. These mice had less adipose tissue compared to their littermates. Adipose tissue in these mice had decreased size and number of adipocytes. With in vitro study using primary cells from tamoxifen-inducible PHF2 KO, we have clarified that PHF2 promotes differentiation of adipocytes. This seemed to be through coactivation of C/EBPα.

Report

(3 results)