• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Association of insulin sensitivity and adipose tissue macrophages

Research Project

Project/Area Number 22790853
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Metabolomics
Research InstitutionUniversity of Toyama

Principal Investigator

FUJISAKA Shiho  富山大学, 大学病院, 医員 (30512082)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords肥満 / 脂肪組織 / インスリン抵抗性 / マクロファージ
Research Abstract

In obese adipose tissues, the number of inflammatory M1 macrophage is dramatically increased and the ratio of antiinflammatory M2 macrophage is reduced, resulting the decrease of insulin sensitivity and development of obesity complications. In this study, I found that telmisartan, an angiotensin II type I receptor blocker, improved insulin resistance with its PPARγactivity, by modulating M1/M2 macrophage ratio(Endocrinology, 152 : 1789-1799, 2011). I also found that obesity-induced hypoxia in adipose tissue is involved in M1 polarization of macrophages.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (13 results)

All 2012 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (6 results) Book (3 results)

  • [Journal Article] The Radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation2012

    • Author(s)
      Watanabe Y., Nakamura T., Ishikawa S., Fujisaka S., Usui I., Tsuneyama K., Ichihara Y., Wada T., Hirata Y., Suganami T., Izaki H., Akira S., Miyake K., Kanayama H., Shimabukuro M., Sata M., Sasaoka T., Ogawa Y., Tobe K., Takatsu K., and Nagai Y
    • Journal Title

      Diabetes

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Telmisartan improves insulin resistance and modulates adipose tissue macrophage polarization in high-fat-fed mice2011

    • Author(s)
      Fujisaka S., Usui I., Kanatani Y., Ikutani M., Takasaki I., Tsuneyama K., Tabuchi Y., Bukhari A., Yamazaki Y., Suzuki H., Senda S., Aminuddin A., Nagai Y., Takatsu K., Kobayashi M., Tobe K.
    • Journal Title

      Endocrinology 2011

      Volume: 152-5 Pages: 1789-99

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deletion of platelet-derived growth factor receptor-βimproves diabetic nephropathy in Ca2+/calmodulin-dependent protein kinase IIα(Thr286 Asp) transgenic mice2011

    • Author(s)
      Suzuki H., Usui I., Kato I., Oya T., Kanatani Y., Yamazaki Y., Fujisaka S., Senda S., Ishii Y., Urakaze M., Mahmood A., Takasawa S., Okamoto H., Kobayashi M., Tobe K., Sasahara M.
    • Journal Title

      Diabetologia 2011

      Volume: 54 Pages: 2953-2962

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Telmisartan Improves Insulin Resistance and Modulates Adipose Tissue Macrophage Polarization in High-Fat-Fed Mice2011

    • Author(s)
      Shiho Fujisaka
    • Journal Title

      Endocrinology

      Volume: 152 Pages: 1789-1799

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 肥満内臓脂肪組織の低酸素環境とM1/M2マクロファージの関連についての検討2012

    • Author(s)
      藤坂志帆
    • Organizer
      日本臨床免疫学会Midwinter Seminar 2012
    • Place of Presentation
      沖縄
    • Year and Date
      2012-02-09
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Obesity-induced hypoxia regulates the polarization of adipose tissue macrophages.2011

    • Author(s)
      Shiho Fujisaka
    • Organizer
      American Diabetes Association's 71st Scientific Sessions
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2011-06-26
    • Related Report
      2011 Final Research Report
  • [Presentation]2011

    • Author(s)
      Shiho Fujisaka
    • Organizer
      American Diabetes Association's 71st Scientific Sessions
    • Place of Presentation
      San Diego, CA
    • Year and Date
      2011-06-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 低酸素環境に対するM1/M2マクロファージの反応性に関する検討2011

    • Author(s)
      藤坂志帆
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 低酸素環境に対するM1/M2マクロファージの反応性に関する検討2010

    • Author(s)
      藤坂志帆
    • Organizer
      Advans研究会2010
    • Place of Presentation
      千葉
    • Year and Date
      2010-12-22
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 脂肪組織M1/M2マクロファージとインスリン抵抗性の関連について2010

    • Author(s)
      藤坂志帆
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2010-05-27
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Book] The Lipid2011

    • Author(s)
      藤坂志帆
    • Total Pages
      5
    • Publisher
      メディカルレビュー社
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Book] medicina2010

    • Author(s)
      藤坂志帆
    • Total Pages
      6
    • Publisher
      医学書院
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Book] Bio Clinica2010

    • Author(s)
      藤坂志帆
    • Total Pages
      5
    • Publisher
      北隆館
    • Related Report
      2011 Final Research Report 2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi