Association of insulin sensitivity and adipose tissue macrophages

• Project/Area Number: 22790853
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: University of Toyama
• Principal Investigator: FUJISAKA Shiho 富山大学, 大学病院, 医員 (30512082)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 肥満 / 脂肪組織 / インスリン抵抗性 / マクロファージ

Research Abstract

In obese adipose tissues, the number of inflammatory M1 macrophage is dramatically increased and the ratio of antiinflammatory M2 macrophage is reduced, resulting the decrease of insulin sensitivity and development of obesity complications. In this study, I found that telmisartan, an angiotensin II type I receptor blocker, improved insulin resistance with its PPARγactivity, by modulating M1/M2 macrophage ratio(Endocrinology, 152 : 1789-1799, 2011). I also found that obesity-induced hypoxia in adipose tissue is involved in M1 polarization of macrophages.

Research Products

• [Journal Article] The Radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation (2012)
  • Author(s): Watanabe Y., Nakamura T., Ishikawa S., Fujisaka S., Usui I., Tsuneyama K., Ichihara Y., Wada T., Hirata Y., Suganami T., Izaki H., Akira S., Miyake K., Kanayama H., Shimabukuro M., Sata M., Sasaoka T., Ogawa Y., Tobe K., Takatsu K., and Nagai Y
  • Journal Title: Diabetes
  • Peer Reviewed
• [Journal Article] Telmisartan improves insulin resistance and modulates adipose tissue macrophage polarization in high-fat-fed mice (2011)
  • Author(s): Fujisaka S., Usui I., Kanatani Y., Ikutani M., Takasaki I., Tsuneyama K., Tabuchi Y., Bukhari A., Yamazaki Y., Suzuki H., Senda S., Aminuddin A., Nagai Y., Takatsu K., Kobayashi M., Tobe K.
  • Journal Title: Endocrinology 2011 Volume: 152-5 Pages: 1789-99
  • Peer Reviewed
• [Journal Article] Deletion of platelet-derived growth factor receptor-βimproves diabetic nephropathy in Ca2+/calmodulin-dependent protein kinase IIα(Thr286 Asp) transgenic mice (2011)
  • Author(s): Suzuki H., Usui I., Kato I., Oya T., Kanatani Y., Yamazaki Y., Fujisaka S., Senda S., Ishii Y., Urakaze M., Mahmood A., Takasawa S., Okamoto H., Kobayashi M., Tobe K., Sasahara M.
  • Journal Title: Diabetologia 2011 Volume: 54 Pages: 2953-2962
  • Peer Reviewed
• [Journal Article] Telmisartan Improves Insulin Resistance and Modulates Adipose Tissue Macrophage Polarization in High-Fat-Fed Mice (2011)
  • Author(s): Shiho Fujisaka
  • Journal Title: Endocrinology Volume: 152 Pages: 1789-1799
  • Peer Reviewed
• [Presentation] 肥満内臓脂肪組織の低酸素環境とM1/M2マクロファージの関連についての検討 (2012)
  • Author(s): 藤坂志帆
  • Organizer: 日本臨床免疫学会Midwinter Seminar 2012
  • Place of Presentation: 沖縄
  • Year and Date: 2012-02-09
• [Presentation] Obesity-induced hypoxia regulates the polarization of adipose tissue macrophages. (2011)
  • Author(s): Shiho Fujisaka
  • Organizer: American Diabetes Association's 71st Scientific Sessions
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2011-06-26
• [Presentation] (2011)
  • Author(s): Shiho Fujisaka
  • Organizer: American Diabetes Association's 71st Scientific Sessions
  • Place of Presentation: San Diego, CA
  • Year and Date: 2011-06-26
• [Presentation] 低酸素環境に対するM1/M2マクロファージの反応性に関する検討 (2011)
  • Author(s): 藤坂志帆
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2011-05-21
• [Presentation] 低酸素環境に対するM1/M2マクロファージの反応性に関する検討 (2010)
  • Author(s): 藤坂志帆
  • Organizer: Advans研究会2010
  • Place of Presentation: 千葉
  • Year and Date: 2010-12-22
• [Presentation] 脂肪組織M1/M2マクロファージとインスリン抵抗性の関連について (2010)
  • Author(s): 藤坂志帆
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-27
• [Book] The Lipid (2011)
  • Author(s): 藤坂志帆
  • Total Pages: 5
  • Publisher: メディカルレビュー社
• [Book] medicina (2010)
  • Author(s): 藤坂志帆
  • Total Pages: 6
  • Publisher: 医学書院
• [Book] Bio Clinica (2010)
  • Author(s): 藤坂志帆
  • Total Pages: 5
  • Publisher: 北隆館