Role of gastric inhibitory polypeptide in modifying pancreatic islet function

• Project/Area Number: 22790857
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: Kyoto University
• Principal Investigator: HAMASAKI Akihiro 京都大学, 大学院・医学研究科, 助教 (40456900)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: インクレチン / GIP / 膵内分泌細胞 / グルカゴン / 糖尿病 / 肥満 / 代謝異常

Research Abstract

We generated gastric inhibitory polypeptide(GIP) receptor conditional knockout mice, and obtained pancreatic beta-cell specific GIP receptor knockout mice. These models enable us to investigate the roles of GIP on pancreatic islet endocrine cells in obesity and diabetes directly.

Research Products

• [Journal Article] The effects of glucose and meal ingestion on incretin secretion in Japanese subjects with normal glucose tolerance (2012)
  • Author(s): Yamane S, Harada N, Hamasaki A, Muraoka A, Joo E, Suzuki K, Tanaka D, Ogura M, Harashima S, Inagaki N
  • Journal Title: J Diabetes Invest Volume: 3(1): 80-85 Issue: 1 Pages: 80-85
  • DOI: 10.1111/j.2040-1124.2011.00143.x
  • Peer Reviewed
• [Journal Article] Analysis of factors influencing postprandial C-peptide levels in Japanese patients with type 2 diabetes : Comparison with C-peptide levels after glucagon load (2011)
  • Author(s): Funakoshi, S., Fujimoto, S., Hamasaki, A., Fujiwara, H., Fujita, Y, Ikeda, K., Takahara, S., Seino, Y, Inagaki, N.
  • Journal Title: Journal of Diabetes Investigation Volume: vol2 Issue: 6 Pages: 429-434
  • DOI: 10.1111/j.2040-1124.2011.00126.x
  • Peer Reviewed
• [Journal Article] Plasma GIP and GLP-1 levels after glucose loading are associated with different factors in Japanese subjects (2011)
  • Author(s): Harada N, Hamasaki A, Muraoka A, Yamane S, Joo E, Fujita K, Inagaki N
  • Journal Title: J Diabetes Invest Volume: 2(3):193-199 Issue: 3 Pages: 186-192
  • DOI: 10.1111/j.2040-1124.2010.00078.x
  • Peer Reviewed
• [Journal Article] The effect of gastric inhibitory polypeptide on intestinal glucose absorption and intestinal motility in mice. (2011)
  • Author(s): Ogawa E, et.al.
  • Journal Title: Biochem Biophys Res Commun Volume: 404 Pages: 115-120
  • Peer Reviewed
• [Journal Article] GLP-1 receptor agonist attenuates ER stress-mediated beta-cell damage in Akita mice. (2010)
  • Author(s): Yamane S, et.al.
  • Journal Title: J.Diabetes Invest. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Plasma gastric inhibitory polypeptide and glucagon-like peptide-1 levels after glucose loading are associated with different factors in Japanese subjects. (2010)
  • Author(s): Harada N, et.al.
  • Journal Title: J.Diabetes Invest. Volume: (in press)
  • Peer Reviewed
• [Presentation] GIPの基礎と臨床 (2012)
  • Author(s): 浜崎暁洋, 原田範夫, 山根俊介, 稲垣暢也
  • Organizer: 日本糖尿病学会近畿地方会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2012-10-29
• [Presentation] GIPの基礎と臨床 (2011)
  • Author(s): 濱崎暁洋、原田範雄、山根俊介、稲垣暢也
  • Organizer: 日本糖尿病学会近畿地方会(シンポジウム)
  • Year and Date: 2011-10-29
• [Presentation] Effects of inhibited GIP secretion on high fat diet-induced obesity and insulin secretion (2011)
  • Author(s): Nasteska, D. Harada, N., Hamasaki, A., Inagaki, N., et al.
  • Organizer: Annual Meeting of the European Society for the Study of Diabetes
  • Place of Presentation: EASD
  • Year and Date: 2011-09-13
• [Presentation] Not glucose tolerance but obesity impairs the numerical incretin effect in Japanese subjects (2011)
  • Author(s): Hamasaki, A., Harada, N., Muraoka, A., Inagaki, N., et al.
  • Organizer: Annual Meeting of the European Society for the Study of Diabetes
  • Place of Presentation: EASD
  • Year and Date: 2011-09-13
• [Presentation] Effects of inhibited GIP secretion on high fat diet-induced obesity and insulin secretion (2011)
  • Author(s): Nasteska, D.Harada, N., Hamasaki, A., Inagaki, N., et al
  • Organizer: Annual Meeting of the European Society for the study of Diabetes (EASD)
  • Place of Presentation: リスボン(ポルトガル)
  • Year and Date: 2011-09-13
• [Presentation] Not glucose tolerance but obesity impairs the numerical incretin effect in Japanese subjects (2011)
  • Author(s): Hamasaki, A., Harada, N., Muraoka, A., Inagaki, N., et al
  • Organizer: Annual Meeting of the European Society for the Study of Diabetes (EASD)
  • Place of Presentation: リスボン(ポルトガル)
  • Year and Date: 2011-09-13
• [Presentation] 日本人の耐糖能とインクレチン効果の検討 (2011)
  • Author(s): 浜崎暁洋, 原田範雄, 村岡敦, 稲垣暢也, 他
  • Organizer: 日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌プリンスホテル
  • Year and Date: 2011-05-19
• [Presentation] Plasma GIP and GLP-1 levels are associated with distinct factors after glucose loading in Japanese subjects. (2010)
  • Author(s): Harada N, et.al.
  • Organizer: The 2^<nd> scientific meeting of the Asian association for the study of diabetes
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-29
• [Presentation] Incretin effect in Japanese subjects. (2010)
  • Author(s): Hamasaki A, et.al.
  • Organizer: The 2^<nd> scientific meeting of the Asian association for the study of diabetes
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-28
• [Presentation] 日本人におけるインクレチン効果の検討 (2010)
  • Author(s): 濱崎暁洋, ほか
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
• [Presentation] GIP-GFP knock-inマウスを用いた高脂肪食肥満におけるGIP分泌の検討 (2010)
  • Author(s): 藤田和代, ほか
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
• [Presentation] Plasma GIP and GLP-1 levels are associated with distinct factors after glucose loading in Japanese subjects. (2010)
  • Author(s): Harada N, et.al.
  • Organizer: America Diabetes Association 70^<nd> scientific sessions
  • Place of Presentation: Orlando, Florida
• [Presentation] Incretin effect in Japanese subjects. (2010)
  • Author(s): Hamasaki A, et.al.
  • Organizer: 8^<th> International Dibetes Federation Western Pacfic Region Congress
  • Place of Presentation: Busan, Korea
• [Remarks]
  • URL: http://metab-kyoto-u.jp/
• [Remarks]
  • URL: http://metab-kyoto-u.jp/to_doctor/achieve_2010.html