Research on new method for evaluating insulin secretion, and association with the genetic factors

• Project/Area Number: 22790862
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: Kobe University
• Principal Investigator: HIROTA Yushi 神戸大学, 医学部附属病院・糖尿病・内分泌内科, 助教 (80566018)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 糖尿病 / 遺伝因子 / インスリン分泌能 / インスリン抵抗性 / 高血糖クランプ / 正常血糖高インスリンクランプ / ディスポジション・インデック / ディスポジション・インデックス

Research Abstract

Disposition index determined by glucose clamp technique (clamp DI) differed significantly among NGT, IGT and T2DM. Clamp DI was decreased with deterioration in glucose tolerance. Therefore, we consider clamp DI as more sensitive measure of beta cell function. We showed the risk allele of KCNQ1, which is the most important disease susceptibility gene identified by Japanese people, was associated with decrease of clamp DI in IGT.

Research Products

• [Journal Article] Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits (2012)
  • Author(s): Fujita H, Hara K, Kadowaki T
  • Journal Title: J Hum Genet Volume: 57 Issue: 12 Pages: 776-779
  • DOI: 10.1038/jhg.2012.110
  • NAID: 10031145885
  • Peer Reviewed
• [Journal Article] C-peptide response to glucagon challenge predicts improvement by liraglutide of both early insulin secretion and glucose tolerance (2012)
  • Author(s): Takabe M, Matsuda T, Hirota Y, Hashimoto N, Nakamura T, Sakaguchi K, Ogawa W, Seino S
  • Journal Title: Diabetes Res Clin Pract Volume: Epub ahead of print Issue: 3 Pages: e32-e35
  • DOI: 10.1016/j.diabres.2012.09.036
  • Peer Reviewed
• [Journal Article] A Minimally Invasive System for Glucose Area under the Curve Measurement using Interstitial Fluid Extraction Technology: Evaluation of the Accuracy and Usefulness with OGTTs in Diabetic and Nondiabetic Subjects (2012)
  • Author(s): Sakaguchi K, Hirota Y, Hashimoto N, Ogawa W, Sato T, Okada S, Hagino K, Asakura Y, Kikkawa Y, Kojima J, Maekawa Y, Nakajima H
  • Journal Title: Diabetes Technol Ther Volume: 14(6) Pages: 485-491
  • Peer Reviewed
• [Journal Article] C-peptide response to glucagon challenge predicts improvement by liraglutide of both early insulin secretion and glucose tolerance. (2012)
  • Author(s): Takabe M et al
  • Journal Title: Diabetes Res Clin Pract Volume: 98
  • Peer Reviewed
• [Journal Article] Age-dependent decline in β-cell function assessed by an oral glucose tolerance test-based disposition index (2011)
  • Author(s): Komada H, Sakaguchi K, Takeda K, Hirota Y, Hashimoto N, Okuno Y, Seino S, Ogawa W
  • Journal Title: Journal of Diabetes Investigation Volume: 2(4) Issue: 4 Pages: 293-296
  • DOI: 10.1111/j.2040-1124.2010.00099.x
  • Peer Reviewed
• [Journal Article] Age-dependent decline in β-cell function assessed by an oral glucose tolerance test-based disposition index (2011)
  • Author(s): Hisako Komada, et al
  • Journal Title: Journal of Diabetes Investigation Volume: 2 Pages: 293-296
  • Peer Reviewed
• [Journal Article] A Minimally Invasive System for Glucose Area under the Curve Measurement using Interstitial Fluid Extraction Technology : Evaluation of the Accuracy and Usefulness with OGTTs in Diabetic and Nondiabetic Subjects
  • Author(s): Kazuhiko Sakaguchi, et al
  • Journal Title: Diabetes Technol Ther Volume: (in press)
  • Peer Reviewed
• [Journal Article] Age-dependent decline in β-cell function assessed by an oral glucose tolerance test-based disposition index
  • Author(s): Hisako Komada, Kazuhiko Sakaguchi, Kazuo Takeda, Yushi Hirota, 以下4名省略
  • Journal Title: Journal of Diabetes Investigation Volume: (in press)
  • Peer Reviewed
• [Presentation] グルコースクランプ法を用いた内分泌疾患における耐糖能の検討 (2013)
  • Author(s): 駒田久子、廣田勇士、坂口一彦、中村友昭、福岡秀規、橋本尚子、井口元三、高橋裕、小川渉、清野進
  • Place of Presentation: 浜松
  • Year and Date: 2013-01-27
• [Presentation] 75g OGTTにおける負荷後1時間血糖値の臨床的意義 (2012)
  • Author(s): 駒田久子、坂口一彦、中村友昭、井口元三、橋本尚子、廣田勇士、小川渉、清野進
  • Organizer: 第49回日本糖尿病学会近畿地方会
  • Place of Presentation: 京都
  • Year and Date: 2012-11-17
• [Presentation] MR Spectroscopy法を用いた正常耐糖能者における膵脂肪蓄積の意義についての検討 (2012)
  • Author(s): 駒田久子ら
  • Organizer: 日本糖尿病学会年次学術集会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 褐色細胞腫術前後におけるインスリン分泌能および抵抗性評価 (2011)
  • Author(s): 井上喜文、坂口一彦、廣田勇士、駒田久子、奥野陽子、近藤奈央、松木核、高部倫敬、松田友和、橋本尚子、井口元三、高橋裕、清野進、小川渉
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2011-05-20
• [Presentation] oral disposition indexによる膵β細胞機能と年齢の関係 (2011)
  • Author(s): 駒田久子、廣田勇士、坂口一彦、奥野陽子、松田友和、橋本尚子、清野進、小川渉
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2011-05-20
• [Presentation] oral disposition indexによる膵β細胞機能と年齢の関係 (2011)
  • Author(s): 駒田久子, et al
  • Organizer: 第54回日本糖尿病学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2011-05-20
• [Presentation] 褐色細胞腫術前後におけるインスリン分泌能および抵抗性評価 (2011)
  • Author(s): 井上喜文, et al
  • Organizer: 第54回日本糖尿病学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2011-05-20
• [Presentation] 内分泌疾患のグルコースクランプによるインスリン分泌抵抗性評価 (2011)
  • Author(s): 井上喜文、坂口一彦、廣田勇士、駒田久子、奥野陽子、近藤奈央、松木核、高部倫敬、松田友和、橋本尚子、井口元三、高橋裕、清野進、小川渉
  • Organizer: 第20回臨床内分泌代謝Update
  • Place of Presentation: 札幌
  • Year and Date: 2011-01-29
• [Presentation] 内分泌疾患のグルコースクランプによるインスリン分泌抵抗性評価 (2011)
  • Author(s): 井上喜文・坂口一彦・廣田勇士, 以下11名省略
  • Organizer: 第20回臨床内分泌代謝Update
  • Place of Presentation: 札幌コンベンションセンター(北海道)(招待講演)
  • Year and Date: 2011-01-29
• [Presentation] 2型糖尿病患者の高血糖クランプ時のインスリン分泌パターンとその臨床像 (2010)
  • Author(s): 駒田久子、坂口一彦、隅田健太郎、神野歩、有村愛子、西海智子、奥野陽子、橋本尚子、廣田勇士、井口元三、小川渉、清野進
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-28
• [Presentation] 75g OGTTにおける負荷後1時間血糖値の臨床的意義
  • Author(s): 駒田久子ら
  • Organizer: 日本糖尿病学会近畿地方会
  • Place of Presentation: 京都国際会館