Effect of intrauterine undernutrition during late gestation on pancreatic beta cell mass.
| Project/Area Number |
22790863
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Kobe University |
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Principal Investigator |
HASHIMOTO Naoko 神戸大学, 大学院・医学研究科, 特命助教 (40559845)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 膵β細胞 / インスリンシグナル / 低出生体重 |
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| Research Abstract |
We examined(1) the assay of the activity on insulin signaling in pancreatic. cells of the mice of food restriction group(RG), and(2) the roles of insulin signaling in pancreatic. cells during catch-up growth using pancreatic. cell-specific PDK1 deficient mouse. Pancreatic. cell mass at birth was decreased in RG offspring as compared to that in control offspring(CG). A high-fat diet significantly increased the pancreatic. cell mass in RG mice as compared to that in CG mice after birth. However, RG mice fed on high-fat diets tended to exhibit a decrease in the pancreatic. cell mass at approximately 24 weeks of age. The pancreatic. cell-specific PDK1 deficient mouse showed the inhibition of increase in pancreatic. cell mass during catch-up growth.
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Report
(3 results)
Research Products
(5 results)
