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Effect of intrauterine undernutrition during late gestation on pancreatic beta cell mass.

Research Project

Project/Area Number 22790863
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Metabolomics
Research InstitutionKobe University

Principal Investigator

HASHIMOTO Naoko  神戸大学, 大学院・医学研究科, 特命助教 (40559845)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords膵β細胞 / インスリンシグナル / 低出生体重
Research Abstract

We examined(1) the assay of the activity on insulin signaling in pancreatic. cells of the mice of food restriction group(RG), and(2) the roles of insulin signaling in pancreatic. cells during catch-up growth using pancreatic. cell-specific PDK1 deficient mouse. Pancreatic. cell mass at birth was decreased in RG offspring as compared to that in control offspring(CG). A high-fat diet significantly increased the pancreatic. cell mass in RG mice as compared to that in CG mice after birth. However, RG mice fed on high-fat diets tended to exhibit a decrease in the pancreatic. cell mass at approximately 24 weeks of age. The pancreatic. cell-specific PDK1 deficient mouse showed the inhibition of increase in pancreatic. cell mass during catch-up growth.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (5 results)

All 2012 2011 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results) Book (2 results)

  • [Journal Article] Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC12012

    • Author(s)
      Koyanagi M, et al
    • Journal Title

      PLoS One

      Volume: 6 Issue: 8 Pages: e23238-e23238

    • DOI

      10.1371/journal.pone.0023238

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Presentation] Effect of intrauterine undernutrition during late gestation on pancreatic beta cell mass2011

    • Author(s)
      Fuchita M
    • Organizer
      47th EASD Annual Meeting
    • Place of Presentation
      リスボン
    • Year and Date
      2011-09-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effect of intrauterine undernutrition during late gestation on pancreatic beta cell mass2010

    • Author(s)
      Fuchita M
    • Organizer
      Asia Islet Biology & Incretin Symposium
    • Place of Presentation
      京都
    • Year and Date
      2010-07-31
    • Related Report
      2010 Annual Research Report
  • [Book] 最新医学2012

    • Author(s)
      淺原俊一郎
    • Total Pages
      7
    • Publisher
      最新医学社
    • Related Report
      2011 Annual Research Report
  • [Book] 内分泌・糖尿病科2010

    • Author(s)
      小柳真希
    • Total Pages
      10
    • Publisher
      科学評論社
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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