Contribution analysis of mitochondrial reactive oxygen species(mtROS) and Hypoxia-Inducible Factor-1(HIF-1) in the molecular mechanism of the metabolic memory

• Project/Area Number: 22790866
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: Kumamoto University
• Principal Investigator: KUKIDOME Daisuke 熊本大学, 医学部附属病院, 医員 (10555759)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: エネルギー / 糖質代謝異常 / 糖尿病合併症 / ミトコンドリアROS / 組織内低酸素

Research Abstract

We previously reported that mitochondrial reactive oxygen species(mtROS) is one of the major factors in the pathogenesis of diabetic vascular complications. In this study, we examined the impact of mtROS in the pathogenesis of diabetic nephropathy using endothelial cells and transgenic mice, which specifically express manganese superoxide dismutase(MnSOD) in vascular endothelial cells.

Research Products

• [Journal Article] A case of cortisol producing adrenal adenoma associated with a latent aldosteronoma : usefulness of the ACTH loading test for the detection of covert aldosteronism in overt Cushing syndrome (2012)
  • Author(s): Kukidome D, Miyamura N, Sakakida K, Shimoda S, Shigematu Y, Nishi K, Yamashita Y, Eto M, Sasano H, Araki E.
  • Journal Title: Intern Med Volume: 51(4) Pages: 395-400
  • NAID: 130002061996
  • Peer Reviewed
• [Journal Article] The effect of group-based lifestyle interventions on risk factors and insulin resistance in subjects at risk for metabolic syndrome : the Tabaruzaka Study 1 (2010)
  • Author(s): Yamashiro T, Nishikawa T, Isami S, Wei CN, Fukumoto K, Matsuo H, Yoshinaga T, Kukidome D, Motoshima H, Matsumura T, Ueda A, Araki E
  • Journal Title: Diabetes Obes Metab Volume: 12(9) Pages: 790-7
• [Presentation] Usefulness of the ACTH administration test in three cases with hypercortisolism and hyperaldosteronism (2011)
  • Author(s): Kukidome D, Koga K, Igata M, Kawashima J, Shimoda S, Shigematu Y, Nishi K, Yamashita Y, Eto M, Sasano H, Miyamura N, Araki E
  • Organizer: ENDO 2011 : The 93nd Annual Meeting & Expo
  • Place of Presentation: USA, Boston
• [Presentation] 2型糖尿病患者での合併症とバランス能力との関連性 (2011)
  • Author(s): 久木留大介、馬場晋平、島村梨紗、嶋田さやか、福永麻希子、古賀荒太郎、本田佳子、大串幹、下田誠也、西川武志、荒木栄一
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: ロイトン札幌
• [Presentation] インスリンからみた糖尿病の病態 (2011)
  • Author(s): 西川武志, 久木留大介, 荒木栄一
  • Organizer: 第45回糖尿病学の進歩
  • Place of Presentation: 福岡国際会議場
• [Presentation] 原発性アルドステロン症に可逆性後白質脳症を併発した一例 (2011)
  • Author(s): 久木留大介、古賀荒太郎、水流添覚、西川武志、宮村信博、荒木栄一
  • Organizer: 第20回臨床内分泌代謝update
  • Place of Presentation: 札幌コンベンションセンター
• [Presentation] 可逆性後白質脳症発症(PLES)を契機に診断に至った原発性アルドステロン症(PA)の一例 (2010)
  • Author(s): 古賀荒太郎、久木留大介、水流添覚、西川武志、宮村信博、荒木栄一
  • Organizer: 第10回日本内分泌学会九州地方会
  • Place of Presentation: 鹿児島大学
  • Year and Date: 2010-08-28
• [Presentation] Mitochondrial reactive oxygen species : A cause and therapeutic target of diabetic complications (2010)
  • Author(s): Nishikawa T, Kukidome D, Araki E
  • Organizer: The 26th Kumamoto Medical Biosciences Symposium
  • Place of Presentation: 熊本大学医学部山崎記念会館, Kumamoto, Japan
  • Year and Date: 2010-06-19
• [Presentation] 2型糖尿病患者における糖尿病合併症と静的・動的バランス能力との関連性 (2010)
  • Author(s): 久木留大介、馬場晋平、島村梨紗、嶋田さやか、福永麻希子、古賀荒太郎、本田佳子、大串幹、下田誠也、西川武志、荒木栄一
  • Organizer: 第48回日本糖尿病学会九州地方会
  • Place of Presentation: 別府ビーコンプラザ
• [Presentation] 酸化ストレスと糖尿病網膜症 (2010)
  • Author(s): 西川武志, 久木留大介, 荒木栄一
  • Organizer: 第25回日本糖尿病合併症学会
  • Place of Presentation: びわ湖ホール・ピアザ淡海
• [Presentation] 静的・動的バランス能力と2型糖尿病患者における糖尿病合併症との関連性 (2010)
  • Author(s): 古賀荒太郎、馬場晋平、島村梨紗、嶋田さやか、福永麻希子、久木留大介、本田佳子^<# 2>、大串幹、下田誠也、西川武志、荒木栄一
  • Organizer: 第60回日本体質医学会総会
  • Place of Presentation: 熊本パレア
• [Presentation] A case of double adenomas in a single adrenal grand associated with primary aldosteronism and hypercortisolism-analysis using the bilateral adrenal venous catheterization and immunohistochemical evaluation of steroidogenesis- (2010)
  • Author(s): Kukidome D, Sakakida K, Sakaguchi M, Furukawa N, Shigematu Y, Nishi K, Ymashita Y Eto M, Sasano H, Miyamura H, Araki E.
  • Organizer: ENDO 2010 : The 92nd Annual Meeting & Expo
  • Place of Presentation: San Diego, USA
• [Presentation] 腎機能障害発症へのインスリン抵抗性とメタボリックシンドロームの関与 (2010)
  • Author(s): 久木留大介、西川武志、山城武司、吉永智昭、本島寛之、松村剛、荒木栄一
  • Organizer: 第53回日本糖尿病学会総会
  • Place of Presentation: ホテルグランビア岡山