Contribution analysis of mitochondrial reactive oxygen species(mtROS) and Hypoxia-Inducible Factor-1(HIF-1) in the molecular mechanism of the metabolic memory
| Project/Area Number |
22790866
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | エネルギー / 糖質代謝異常 / 糖尿病合併症 / ミトコンドリアROS / 組織内低酸素 |
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| Research Abstract |
We previously reported that mitochondrial reactive oxygen species(mtROS) is one of the major factors in the pathogenesis of diabetic vascular complications. In this study, we examined the impact of mtROS in the pathogenesis of diabetic nephropathy using endothelial cells and transgenic mice, which specifically express manganese superoxide dismutase(MnSOD) in vascular endothelial cells.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] The effect of group-based lifestyle interventions on risk factors and insulin resistance in subjects at risk for metabolic syndrome : the Tabaruzaka Study 12010
Author(s)
Yamashiro T, Nishikawa T, Isami S, Wei CN, Fukumoto K, Matsuo H, Yoshinaga T, Kukidome D, Motoshima H, Matsumura T, Ueda A, Araki E
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Journal Title
Diabetes Obes Metab
Volume: 12(9)
Pages: 790-7
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[Presentation] Usefulness of the ACTH administration test in three cases with hypercortisolism and hyperaldosteronism2011
Author(s)
Kukidome D, Koga K, Igata M, Kawashima J, Shimoda S, Shigematu Y, Nishi K, Yamashita Y, Eto M, Sasano H, Miyamura N, Araki E
Organizer
ENDO 2011 : The 93nd Annual Meeting & Expo
Place of Presentation
USA, Boston
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[Presentation] A case of double adenomas in a single adrenal grand associated with primary aldosteronism and hypercortisolism-analysis using the bilateral adrenal venous catheterization and immunohistochemical evaluation of steroidogenesis-2010
Author(s)
Kukidome D, Sakakida K, Sakaguchi M, Furukawa N, Shigematu Y, Nishi K, Ymashita Y Eto M, Sasano H, Miyamura H, Araki E.
Organizer
ENDO 2010 : The 92nd Annual Meeting & Expo
Place of Presentation
San Diego, USA
Related Report
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