Analysis of mechanism(s) on hypoglycemia unawareness-relevant to increment of brain glycogen via adenosine-

• Project/Area Number: 22790867
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: Kumamoto University
• Principal Investigator: KAWASHIMA Junji 熊本大学, 大学院・生命科学研究部, 助教 (70467984)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
• Keywords: エネルギー / 糖質代謝異常 / 脳・神経 / シグナル伝達

Research Abstract

Brain glycogen level was apparently reduced 2 hr after subcutaneous injection of insulin and was recovered to basal level 6 hr after insulin injection. Brain glycogen level in insulin injected rat was significantly increased 24 hr after subcutaneous injection of insulin, compared to saline injected rat. Subcutaneous or intracerebroventricular injection of adenosine receptor antagonist did not inhibit the increment of brain glycogen after recovery of insulin-induced hypoglycemia. Therefore, it was suggested that the recovery of brain glycogen after hypoglycemia was not involved in adenosine signaling.