Roles of hypothalamic S6 kinase on diabetes
Project/Area Number |
22790869
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Metabolomics
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Research Institution | Saitama Medical University |
Principal Investigator |
ONO Hiraku 埼玉医科大学, 医学部, 講師 (10570616)
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | エネルギー・糖質代謝異常 / インスリン抵抗性 / インスリン / LKB1 / 肝臓 / PTEN / Akt / 視床下部 / S6キナーゼ / 摂食 / 糖尿病 / AMPK / GSK3 / 糖負荷試験 |
Research Abstract |
(1) The expression of LKB1 in the liver of db/db mouse was decreased compared to the control mouse. LKB1 rescue in db/db mouse liver by expression vector improved glycemic control.(2) Inhibition of PTEN, the upstream regulator of S6 kinase, in the hypothalamic arcuate nucleus by an expression vector suppressed food intake and body weight gain, but this effect was blunted by overfeeding. PTEN inhibition in the arcuate nucleus improved insulin sensitivity independent to body weight.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with IRS-1 and enhances insulin actions and adipogenesis2011
Author(s)
Nakatsu Y, Sakoda H, Kushiyama A, Zhang J, Ono H, Fujishiro M, Kikuchi T, Fukushima T, Yoneda M, Ohno H, Horike N, Kanna M, Tsuchiya Y, Kamata H, Nishimura F, Isobe T, Ogihara T, Katagiri H, Oka Y, Takahashi SI, Kurihara H, Uchida T, Asano T
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Journal Title
J Biol Chem
Volume: 286
Issue: 23
Pages: 20812-20822
DOI
Related Report
Peer Reviewed
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[Journal Article] 4F2hc stabilizes GLUT1 protein and increases glucose transport activity2011
Author(s)
Ohno H, Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Otani Y, Okubo H, Yoneda M, Fukushima T, Kamata H, Nishimura F, Kurihara H, Katagiri H, Oka Y, Asano T
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Journal Title
Am J Physiol Cell Physiol
Volume: 300(5)
Issue: 5
Pages: 1047-54
DOI
Related Report
Peer Reviewed
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[Journal Article] Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing CRE transcriptional activity2010
Author(s)
Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Horike N, Yoneda M, Ohno H, Kamata H, Tahara H, Isobe T, Nishimura F, Katagiri H, Oka Y, Fukushima T, Takahashi SI, Kurihara H, Uchida T, Asano T
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Journal Title
J Biol Chem
Volume: 285
Pages: 33018-27
Related Report
Peer Reviewed
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[Journal Article] Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy2010
Author(s)
Cui X, Kushiyama A, Yoneda M, Nakatsu Y, Guo Y, Zhang J, Ono H, Kanna M, Sakoda H, Ono H, Kikuchi T, Fujishiro M, Shiomi M, Kamata H, Kurihara H, Kikuchi M, Kawazu S, Nishimura F, Asano T
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Journal Title
Diabetes Res Clin Pract
Volume: 87
Pages: 57-63
Related Report
Peer Reviewed
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