Role of human CRP and TACE in the Pathogenesis of Adipose Tissue Remodeling and Insulin Resistance

• Project/Area Number: 22790871
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: Keio University
• Principal Investigator: KANEKO Hidehiro 慶應義塾大学, 医学部, 共同研究員 (70468510)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 内臓脂肪リモデリング / インスリン抵抗性 / 慢性炎症 / C反応蛋白 / TACE

Research Abstract

We aimed to clarify the role of human C-reactive protein(CRP) and TACE in the development of adipose tissue remodeling and metabolic disorders. Human CRP transgenic mice showed exacerbated adipose tissue remodeling, insulin resistance and hepatosteatosis under high-fat diet feeding. In contrast, TACE ablation mice prevented high-fat diet induced body weight gain, adipose tissue remodeling and metabolic disorders. These experiments might suggest the crucial role of human CRP and TACE in the pathogenesis of adipose tissue remodeling and metabolic disorders under high-fat diet feeding.

Research Products

• [Journal Article] Human C-reactive protein exacerbates metabolic disorders in association with adipose tissue remodeling (2011)
  • Author(s): Kaneko H, Anzai T, Nagai T, Anzai A, Takahashi T, Mano M, Morimoto K, Maekawa Y, Itoh H, Yoshikawa T, Ogawa S, Fukuda K
  • Journal Title: Cardiovasc Res Volume: 91(3) Pages: 546-55
  • Peer Reviewed
• [Journal Article] Tumor necrosis factor-α converting enzyme inactivation ameliorates high-fat diet-induced insulin resistance and altered energy homeostasis (2011)
  • Author(s): Kaneko H, Anzai, T, Horiuchi, K, Morimoto K, Anzai A, Nagai T, Maekawa Y, Itoh H, Yoshikawa T, Okada Y, Ogawa S, Fukuda K
  • Journal Title: Circ J Volume: 75(10) Pages: 2482-90
  • NAID: 10029459912
  • Peer Reviewed
• [Journal Article] Human C-reactive protein exacerbates metabolic disorders in association with adipose tissue remodeling (2011)
  • Author(s): Hidehiro Kaneko
  • Journal Title: Cardiovascular Research Volume: 91 Pages: 546-55
  • Peer Reviewed
• [Journal Article] Tumor necrosis factor-□ converting enzyme inactivation ameliorates high-fat diet-induced insulin resistance and altered energy homeostasis (2011)
  • Author(s): Hidehiro Kaneko
  • Journal Title: Circulation Journal Volume: 218
  • Peer Reviewed
• [Journal Article] Tumor necrosis factor-〓 converting enzyme inactivation ameliorates high-fat diet-induced insulin resistance and altered energy homeostasis (2011)
  • Author(s): Hidehiro Kaneko
  • Journal Title: Circulation Journal Volume: 218 Pages: 2482-90
  • Peer Reviewed
• [Presentation] Human C-reactive protein exacerbates obesity induced insulin resistance and hepatosteatosis associated with adipose tissue remodeling (2010)
  • Author(s): Kaneko H, Anza i T, Takah ashi T, Morimoto K, Maekawa Y, Itoh H, Yoshikawa T, Ogawa S, Fukuda K
  • Organizer: ESC CONGRESS 2010
  • Place of Presentation: Stockholm, Sweden
• [Presentation] Temporal Systemic Deletion of Tumor Necrosis Factor-α Converting Enzyme Prevents Development of High-Fat Diet-induced Insulin Resistance, Hepatosteatosis, Adipose Tissue Remodeling with Ameliorating Energy Expenditure (2010)
  • Author(s): Kaneko H, Anzai T, Horiuchi K, Morimoto K, Itoh H, Okada Yasunori, Yoshikawa T, Ogawa S, Fukuda K
  • Organizer: American Heart Association Scientific Sessions 2010
  • Place of Presentation: Chicago, IL, USA