| Project/Area Number |
22790873
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Metabolomics
|
|---|
| Research Institution | Kinki University |
|---|
Principal Investigator |
|
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Keywords | 酸化ストレス / 小胞体ストレス / インスリン抵抗性 / 臓器障害 / ASK1 / 糖尿病 / ASK / 2型糖尿病 |
|---|
| Research Abstract |
In diabetes, ASK-JNK pathway is considerably involved to oxidative stress and endoplasmic reticulum stress. So, we could think that this pathway was key pathway to improve insulin resistance. Moreover, to adjust this ASK-JNK pathway it can become a therapeutic target to type 2 diabetic patients, and it expects a possibility that this intervention will lead to prevention and slowly progression of diabetic complication in the future.
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