| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Patients with chronic liver disease and insulin resistance frequently develop hepatocellular carcinoma, leading to poor progosis. Recently, insulin resistance is reported to be involved in the development of not only cardio-vascular disease, but also epithelial-mesenchymal transition, which link to carcinogenesis and malignant potential of tumor cells. Although molecular mechanism(s) for an association of insulin resistance and epithelial-mesenchymal transition is not fully elucidated in hepatocarcinogenesis, we have demonstrated that interleukin-6 promoted epithelial-mesenchymal transition in a hepatoma cell line cultured with insulin in this study. We further showed that dipeptidyl deptidase-4 inhibitor suppressed interleukin-6-caused epithelial-mesenchymal transition in HepG2 cells.
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