The cytobiological impact of insulin resistance on BMPs-related epithelial-mesenchymal transition of hepatocellular carcinoma
| Project/Area Number |
22790874
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | インスリン抵抗性 / 肝細胞癌 / 肝臓癌 / 上皮間葉移行 / dipeptidyl deptidase-4 / IL-6 / glucagon-like peptide-1 / dipeptidyl deptidase-4阻害剤 / ピオグリタゾン / 糖尿病 / tuberin / mTOR / 細胞増殖 / インスリン情報伝達経路 / HOMA-IR / 2型糖尿病 |
|---|
| Research Abstract |
Patients with chronic liver disease and insulin resistance frequently develop hepatocellular carcinoma, leading to poor progosis. Recently, insulin resistance is reported to be involved in the development of not only cardio-vascular disease, but also epithelial-mesenchymal transition, which link to carcinogenesis and malignant potential of tumor cells. Although molecular mechanism(s) for an association of insulin resistance and epithelial-mesenchymal transition is not fully elucidated in hepatocarcinogenesis, we have demonstrated that interleukin-6 promoted epithelial-mesenchymal transition in a hepatoma cell line cultured with insulin in this study. We further showed that dipeptidyl deptidase-4 inhibitor suppressed interleukin-6-caused epithelial-mesenchymal transition in HepG2 cells.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Hybrid training of voluntary and electrical muscle contractions reduces steatosis, insulin resistance, and IL-6 levels in patients with NAFLD: a pilot study.2011
Author(s)
Kawaguchi T, Shiba N, Maeda T, Matsugaki T, Takano Y, Itou M, Sakata M, Taniguchi E, Nagata K, Sata M.
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Journal Title
J Gastroenterol.
Volume: 46
Issue: 6
Pages: 746-57
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] Sata M. GLP-1R agonist increased glucose uptake and inhibited GSK3β phosphorylation through the AMPK signaling pathways in human hepatocytes.2012
Author(s)
Itou M, Kawaguchi T, Sakata M, Taniguchi E, Sumie S, Oriishi T, Mitsuyama K, Torimura T, Tsuruta O
Organizer
Digestive Disease Week2012.
Place of Presentation
San Diego, California, USA.
Year and Date
2012-05-19
Related Report
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[Presentation] Hybrid-training of voluntary and electrical muscle contractions improves nonalcoholic fatty liver disease and reduces insulin resistance and interleukin-6 levels.2010
Author(s)
Kawaguchi T, Shiba N, Maeda T, Matsugaki T, Takano Y, Itou M, Sakata M, Taniguchi E, Nagata K, Sata M.
Organizer
The 61st Annual Meeting of the American Association for the Study of the Liver Disease.
Place of Presentation
Boston, Massachusetts, USA.
Year and Date
2010-10-30
Related Report
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