R oleofadipocyte-pcificmRNAregulatorysysteminthecontrol ofinsulin-mediatedglesucosemetabolism

• Project/Area Number: 22790879
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: National Center for Geriatrics and Gerontology
• Principal Investigator: SUGIMOTO Masataka 独立行政法人国立長寿医療研究センター, 老化細胞研究プロジェクトチーム, プロジェクトリーダー (50426491)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: RNA結合タンパク質 / 脂肪細胞 / 翻訳

Research Abstract

Adipocytes play essential roles in controlling the insulin sensitivity. We have previously shown that an RNA-binding protein Hzf is specifically expressed inadipose tissue and required for proper adipocyte functions thereby contributing to theregulation of insulin-mediated glucose metabolism. We here investigate the detailed molecular mechanism by which Hzf functions in adipocytes and show that Hzf associateswith another RNA-binding protein HuR. These proteins cooperate in the regulation of geneexpression through post-transcriptional mechanism, which is required for the adipocytefunctions.

Research Products

• [Journal Article] Cooperative role of the RNA-binding proteins Hzf and HuR in p53 activation (2011)
  • Author(s): Nakamura H,Kawagishi H,Watanabe A, Sugimoto K, Maruyama M, Sugimoto M
  • Journal Title: Mol Cell Biol Volume: 31 Issue: 10 Pages: 101997-2009
  • DOI: 10.1128/mcb.01424-10
  • Peer Reviewed
• [Presentation] HuR maintains replicative lifespan by repressing ARF tumor suppressor (2011)
  • Author(s): Kawagishi, H., Nakamura, H., Tsugawa, T. and Sugimoto, M
  • Organizer: 第34回大会日本分子生物学会年会横浜
  • Year and Date: 2011-12-14
• [Presentation] HuR maintains replicative lifespan by repressing ARF tumor suppressor (2011)
  • Author(s): Hiroyuki Kawagishi
  • Organizer: 日本分子生物学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-12-14
• [Presentation] RNA-binding protein HuR suppressescellular lifespan by repressing the translation of ARF mRNA (2011)
  • Author(s): Kawagishi, H. and Sugimoto, M
  • Organizer: Mechanism and Model of Cancer, SALK symposia
  • Year and Date: 2011-08-17
• [Presentation] RNA-binding protein HuR suppresses cellular lifespan by repressing the translation of ARF mRNA (2011)
  • Author(s): Hiroyuki Kawagishi
  • Organizer: SALK symposia
  • Place of Presentation: Salk Institute
  • Year and Date: 2011-08-11
• [Presentation] Post-transcriptional regulation of the p53 tumor suppressor (2010)
  • Author(s): Nakamura, H., Kawagishi, H., Watanabe, A, Maruyama, M., Sugimoto, M
  • Organizer: Molecular Genetics of Aging, Cold Spring Harbor Laboratory Meeting
  • Year and Date: 2010-08-18
• [Presentation] Post-transcriptionalregulation of the p53 pathway (2010)
  • Author(s): Sugimoto, M
  • Organizer: 日本基礎老化学会第33回大会シンポジウム愛知県
  • Year and Date: 2010-06-17
• [Presentation] Post-transcriptional regulation of the p53 pathway (2010)
  • Author(s): 杉本昌隆
  • Organizer: 基礎老化学会シンポジウム
  • Place of Presentation: 名古屋大学
  • Year and Date: 2010-06-17