Regulatory mechanisms of p27kip1 and its significance by non-genomic action of thyroid hormone.

• Project/Area Number: 22790884
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Endocrinology
• Research Institution: Nagoya University
• Principal Investigator: CAO Xia 名古屋大学, 環境医学研究所, 助教 (70432218)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 甲状腺ホルモン / ノンゲノミック作用 / p27kip1

Research Abstract

T3 inhibited the ubiquitination of p27^<Kip1> the through inducing the Thr187 phospholylation of p27^<Kip1>, and thus enhanced p27^<Kip1> expression. This further promoted the cell differentiation and inhibited cell proliferation.