| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
BMP-15 is a TGF-βsuperfamily member and produced in oocytes within the ovary. BMP-15 has recently been recognized as a candidate factor that may be involved in premature ovarian failure. In this study, BMP-15 mutants identified in premature ovarian failure patients decreased biological activities compared with wild-type, partially due to reduced production of mature protein. Loss of posttranslational phosphorylation of mature BMP-15 also resulted in impaired biological activities. These results are important to elucidate the mechanism in which BMP-15 exerts the various effects on human female reproduction.
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