| Project/Area Number |
22790888
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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|---|
| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 再生医学 / 発生・分化 / 遺伝子 / iPS細胞 / 間葉系細胞分化 / 核内受容体 / エストロゲン関連受容体 |
|---|
| Research Abstract |
To elucidate the functional roles of estrogen related receptors(ERRs) on the reprogramming and differentiation of mesenchymal-derived cells, we examined combined methods achieving efficient reprogramming and mesenchymal-derived cell differentiation using viral vector systems. This made a partly improved efficiency of differentiation, while it was demonstrated that differentiation potential of iPS cells varied widely between clones. In this study, we established the basis for evaluation of ERR functions in reprogramming and differentiation, while these results suggest that generation of genetically and functionally homogenous iPS cells is necessary for in vivo evaluation of gene function as well as clinical application of iPS cells.
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