The role of Notch signaling in megakaryocytopoiesis

• Project/Area Number: 22790896
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Hematology
• Research Institution: University of Tsukuba
• Principal Investigator: NISHIKII Hidekazu 筑波大学, 医学医療系, 講師 (30512834)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 血栓 / 止血学 / 巨核球 / 分化運命 / Notchシグナル / 造血幹細胞 / Hes1 / レトロウイルス / センダイウイルス

Research Abstract

To clarify the precise differentiation pathway of megakaryocyte lineage from hematopoietic stem cell and the role of Notch signaling during megakaryocytopoiesis, we identified a new class of megakaryocyte progenitors in the adult mouse bone marrow and demonstrated the gene expression pattern (including Notch signal molecules).