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Genome-wide analysis of acute myeloid leukemia using high-density oligonucleotide arrays

Research Project

Project/Area Number 22790900
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Hematology
Research InstitutionThe University of Tokyo

Principal Investigator

NAKAZAKI Kumi  東京大学, 保健・健康推進本部, 助教 (70550432)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords急性骨髄性白血病 / SNPアレイ / 遺伝子解析 / ゲノム / アレイ解析 / 癌
Research Abstract

Genome-wide analysis with single nucleotide polymorphisms(SNP) arrays was conducted for samples from 103 cases with acute myeloid leukemia(AML). We applied high-resolution oligonucleotide microarrays(GeneChip(R) 100K or 500K arrays) which enabled us to detect allele specific copy number alterations in tumors systemically and sensitively. As a result, Lots of chromosomal aberrations including very small regions were shown in this study, and uniparental disomy was detected in 29% of AML. Homozygous mutations were highly frequently in UPD regions.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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