Analysis of the mechanism of stem cell and niche-regulating function of refractory leukemia-related molecule, BAALC
| Project/Area Number |
22790901
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 血液内科学 / 白血病 / 幹細胞 |
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| Research Abstract |
The BAALC(brain and acute leukemia, cytoplasmic) gene is known to be highly expressed in the acute myeloid leukemia cells with poor prognosis, however, its function in normal and malignant hematopoiesis has not been known. Using gene-targeted mice, this study elucidated a critical role for BAALC in regulating the hematopoietic stem cell niche in the bone marrow through the p53 pathway. These results identified BAALC as a novel stem cell regulating gene, and lead to a molecular targeted therapy for the refractory leukemia.
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Report
(3 results)
Research Products
(37 results)
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[Journal Article] AML1/RUNX1 functions as a cytoplasmic attenuator of NF-ホコB signaling in the repression of myeloid tumors2011
Author(s)
Nakagawa M, Shimabe M, Watanabe-Okochi N, Arai S, Yoshimi A, Shinohara A, Nishimoto N, Kataoka K, Sato T, Kumano K, Nannya Y, Ichikawa M, Imai Y, Kurokawa M
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Journal Title
Blood
Volume: 118
Pages: 6626-6637
Related Report
Peer Reviewed
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