| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
The BAALC(brain and acute leukemia, cytoplasmic) gene is known to be highly expressed in the acute myeloid leukemia cells with poor prognosis, however, its function in normal and malignant hematopoiesis has not been known. Using gene-targeted mice, this study elucidated a critical role for BAALC in regulating the hematopoietic stem cell niche in the bone marrow through the p53 pathway. These results identified BAALC as a novel stem cell regulating gene, and lead to a molecular targeted therapy for the refractory leukemia.
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