Effect of WTX, a tumor suppressor gene associated with Wilms' tumor, on hematopoiesis and leukemogenesis
| Project/Area Number |
22790902
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 血液内科学 / WTX / 点突然変異 / DNAメチル化 / イントロン1 / CpGアイランド |
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| Research Abstract |
Tumor suppressor gene, WTX, is most strongly expressed in hematopoietic stem cells(HSCs), and is likely to regulate self-renewal and maintenance of HSCs. Although we identified point mutations of WTX gene a portion of acute myeloid leukemia, mutant WTX was not functionally different from wild-type WTX. Rather, WTX was markedly down-regulated in T-cell acute lymphoblastic leukemia, where DNA methylation seems to play pivotal roles.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] Composite diffuse large B-cell lymphoma and CD20-positive peripheral T-cell lymphoma2011
Author(s)
Yamazaki S, Fujioka Y, Nakamura F, Ota S, Shinozaki A, Yamamoto G, Kamikubo Y, Nannya Y, Ichikawa M, Fukayama M, Kurokawa M
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Journal Title
Pathol Int
Volume: 61
Pages: 662-6
NAID
Related Report
Peer Reviewed
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