| Project/Area Number |
22790902
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | 血液内科学 / WTX / 点突然変異 / DNAメチル化 / イントロン1 / CpGアイランド |
|---|
| Research Abstract |
Tumor suppressor gene, WTX, is most strongly expressed in hematopoietic stem cells(HSCs), and is likely to regulate self-renewal and maintenance of HSCs. Although we identified point mutations of WTX gene a portion of acute myeloid leukemia, mutant WTX was not functionally different from wild-type WTX. Rather, WTX was markedly down-regulated in T-cell acute lymphoblastic leukemia, where DNA methylation seems to play pivotal roles.
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